4QFC
Co-crystal structure of compound 3 (4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2h-chromen-6-yl)ethyl]pyridazin-3(2h)-one) and FAD bound to human DAAO at 2.4A
Summary for 4QFC
Entry DOI | 10.2210/pdb4qfc/pdb |
Related | 4QFD |
Descriptor | D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)ethyl]pyridazin-3(2H)-one, ... (5 entities in total) |
Functional Keywords | oxidase, oxidoreductase, daao, d-amino acid oxidase, fad dependent, nmdar, schizophrenia, d-serine competitive, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Peroxisome: P14920 |
Total number of polymer chains | 2 |
Total formula weight | 81404.74 |
Authors | Lukacs, C.M.,Chun, L. (deposition date: 2014-05-20, release date: 2014-07-16, Last modification date: 2023-09-20) |
Primary citation | Terry-Lorenzo, R.T.,Chun, L.E.,Brown, S.P.,Heffernan, M.L.,Fang, Q.K.,Orsini, M.A.,Pollegioni, L.,Hardy, L.W.,Spear, K.L.,Large, T.H. Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation. Biosci.Rep., 34:-, 2014 Cited by PubMed: 25001371DOI: 10.1042/BSR20140071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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