4QFD
Co-crystal structure of compound 2 (3-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)propanoic acid) and FAD bound to human DAAO at 2.85A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003884 | molecular_function | D-amino-acid oxidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005737 | cellular_component | cytoplasm |
A | 0005741 | cellular_component | mitochondrial outer membrane |
A | 0005777 | cellular_component | peroxisome |
A | 0005782 | cellular_component | peroxisomal matrix |
A | 0005829 | cellular_component | cytosol |
A | 0006562 | biological_process | proline catabolic process |
A | 0007586 | biological_process | digestion |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019478 | biological_process | D-amino acid catabolic process |
A | 0036088 | biological_process | D-serine catabolic process |
A | 0042416 | biological_process | dopamine biosynthetic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0042995 | cellular_component | cell projection |
A | 0045202 | cellular_component | synapse |
A | 0046416 | biological_process | D-amino acid metabolic process |
A | 0048786 | cellular_component | presynaptic active zone |
A | 0055130 | biological_process | D-alanine catabolic process |
A | 0070178 | biological_process | D-serine metabolic process |
A | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
A | 0071949 | molecular_function | FAD binding |
B | 0003884 | molecular_function | D-amino-acid oxidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005737 | cellular_component | cytoplasm |
B | 0005741 | cellular_component | mitochondrial outer membrane |
B | 0005777 | cellular_component | peroxisome |
B | 0005782 | cellular_component | peroxisomal matrix |
B | 0005829 | cellular_component | cytosol |
B | 0006562 | biological_process | proline catabolic process |
B | 0007586 | biological_process | digestion |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019478 | biological_process | D-amino acid catabolic process |
B | 0036088 | biological_process | D-serine catabolic process |
B | 0042416 | biological_process | dopamine biosynthetic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0042995 | cellular_component | cell projection |
B | 0045202 | cellular_component | synapse |
B | 0046416 | biological_process | D-amino acid metabolic process |
B | 0048786 | cellular_component | presynaptic active zone |
B | 0055130 | biological_process | D-alanine catabolic process |
B | 0070178 | biological_process | D-serine metabolic process |
B | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
B | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA A 401 |
Chain | Residue |
A | LEU122 |
A | PHE125 |
A | PRO126 |
A | TYR128 |
site_id | AC2 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE FAD A 402 |
Chain | Residue |
A | ALA36 |
A | ASP37 |
A | ARG38 |
A | THR44 |
A | THR45 |
A | VAL47 |
A | ALA48 |
A | ALA49 |
A | GLY50 |
A | LEU51 |
A | ARG162 |
A | VAL164 |
A | CYS181 |
A | THR182 |
A | GLY183 |
A | TRP185 |
A | GLY281 |
A | ARG283 |
A | GLY312 |
A | GLY313 |
A | TYR314 |
A | GLY315 |
A | LEU316 |
A | THR317 |
A | 31R403 |
A | HOH503 |
A | HOH504 |
A | HOH505 |
A | GLY7 |
A | ALA8 |
A | GLY9 |
A | VAL10 |
A | ILE11 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 31R A 403 |
Chain | Residue |
A | GLN53 |
A | PRO54 |
A | TYR55 |
A | LEU56 |
A | THR216 |
A | HIS217 |
A | TYR224 |
A | SER226 |
A | TYR228 |
A | ARG283 |
A | GLY313 |
A | FAD402 |
A | HOH508 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA B 401 |
Chain | Residue |
B | LEU122 |
B | PHE125 |
B | PRO126 |
B | TYR128 |
site_id | AC5 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE FAD B 402 |
Chain | Residue |
B | GLY7 |
B | ALA8 |
B | GLY9 |
B | VAL10 |
B | ILE11 |
B | ALA36 |
B | ASP37 |
B | ARG38 |
B | THR44 |
B | THR45 |
B | ALA48 |
B | ALA49 |
B | GLY50 |
B | LEU51 |
B | ARG162 |
B | VAL164 |
B | THR182 |
B | GLY183 |
B | TRP185 |
B | ILE202 |
B | GLY281 |
B | ARG283 |
B | GLY312 |
B | GLY313 |
B | TYR314 |
B | GLY315 |
B | LEU316 |
B | THR317 |
B | 31R403 |
site_id | AC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE 31R B 403 |
Chain | Residue |
B | GLN53 |
B | PRO54 |
B | TYR55 |
B | TYR224 |
B | SER226 |
B | TYR228 |
B | ARG283 |
B | GLY313 |
B | FAD402 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ALA8 | |
A | ILE11 | |
B | ALA8 | |
B | ILE11 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17303072, ECO:0007744|PDB:2E4A, ECO:0007744|PDB:2E82 |
Chain | Residue | Details |
A | GLY9 | |
B | GLY9 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17088322, ECO:0000269|PubMed:23566269, ECO:0000269|PubMed:23631755, ECO:0007744|PDB:2DU8, ECO:0007744|PDB:3W4I, ECO:0007744|PDB:3W4J, ECO:0007744|PDB:3W4K, ECO:0007744|PDB:3ZNO, ECO:0007744|PDB:3ZNQ |
Chain | Residue | Details |
A | VAL10 | |
B | VAL10 |
Chain | Residue | Details |
A | ASP37 | |
B | ASP37 |
Chain | Residue | Details |
A | ARG38 | |
B | VAL164 | |
B | GLY312 | |
B | THR317 | |
A | THR45 | |
A | LEU51 | |
A | VAL164 | |
A | GLY312 | |
A | THR317 | |
B | ARG38 | |
B | THR45 | |
B | LEU51 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18455394, ECO:0007744|PDB:3CUK |
Chain | Residue | Details |
A | THR43 | |
B | THR43 |
Chain | Residue | Details |
A | THR44 | |
B | THR44 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00371 |
Chain | Residue | Details |
A | ALA49 | |
A | LYS163 | |
B | ALA49 | |
B | LYS163 |
Chain | Residue | Details |
A | GLY50 | |
B | GLY50 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17303072, ECO:0007744|PDB:2E82 |
Chain | Residue | Details |
A | GLN53 | |
B | GLN53 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0007744|PDB:3ZNQ |
Chain | Residue | Details |
A | THR182 | |
B | THR182 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:17303072, ECO:0007744|PDB:2E4A |
Chain | Residue | Details |
A | TYR224 | |
B | TYR224 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:17088322, ECO:0000305|PubMed:17303072, ECO:0000305|PubMed:18455394, ECO:0007744|PDB:2DU8, ECO:0007744|PDB:2E4A, ECO:0007744|PDB:3CUK |
Chain | Residue | Details |
A | TYR228 | |
B | TYR228 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17303072, ECO:0000269|PubMed:18455394, ECO:0000269|PubMed:23566269, ECO:0000269|PubMed:23631755, ECO:0007744|PDB:2E48, ECO:0007744|PDB:2E49, ECO:0007744|PDB:2E82, ECO:0007744|PDB:3CUK, ECO:0007744|PDB:3W4I, ECO:0007744|PDB:3W4J, ECO:0007744|PDB:3W4K, ECO:0007744|PDB:3ZNO |
Chain | Residue | Details |
A | ARG283 | |
B | ARG283 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17088322, ECO:0000269|PubMed:17303072, ECO:0000269|PubMed:23566269, ECO:0000269|PubMed:23631755, ECO:0000269|PubMed:25001371, ECO:0007744|PDB:2DU8, ECO:0007744|PDB:2E48, ECO:0007744|PDB:2E49, ECO:0007744|PDB:2E82, ECO:0007744|PDB:3W4I, ECO:0007744|PDB:3W4J, ECO:0007744|PDB:3W4K, ECO:0007744|PDB:3ZNO, ECO:0007744|PDB:3ZNP, ECO:0007744|PDB:3ZNQ, ECO:0007744|PDB:4QFD |
Chain | Residue | Details |
A | GLY313 | |
B | GLY313 |
Chain | Residue | Details |
A | GLY315 | |
B | GLY315 |
Chain | Residue | Details |
A | LEU316 | |
B | LEU316 |