4REW

Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex

Summary for 4REW

• Entry DOI: 10.2210/pdb4rew/pdb
• Related: 4RED 4RER
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... (5 entities in total)
• Functional Keywords: human alpha1 beta2 gamma1 holo-ampk complex, serine/threonine protein kinase, axin, camkkbeta, lkb1, glycogen, phosphorylation, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : Q13131
• Total number of polymer chains: 3
• Total formula weight: 120008.98

Authors

Zhou, X.E.,Ke, J.,Li, X.,Wang, L.,Gu, X.,de Waal, P.W.,Tan, M.H.E.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K. (deposition date: 2014-09-24, release date: 2014-12-10, Last modification date: 2023-09-20)

• Primary citation: Li, X.,Wang, L.,Zhou, X.E.,Ke, J.,de Waal, P.W.,Gu, X.,Tan, M.H.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K.; Structural basis of AMPK regulation by adenine nucleotides and glycogen.; Cell Res., 25:50-66, 2015; PubMed: 25412657; DOI: 10.1038/cr.2014.150

Experimental method

X-RAY DIFFRACTION (4.58 Å)