4REW
Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 540 | 61486.2 | 1 | UniProt (Q13131) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB | Homo sapiens (human) | AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1 |
| 2 | B | 5'-AMP-activated protein kinase subunit beta-2 | polymer | 197 | 22369.5 | 1 | UniProt (O43741) Pfam (PF16561) Pfam (PF04739) In PDB | Homo sapiens (human) | AMPK subunit beta-2 |
| 3 | G | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 304 | 34645.1 | 1 | UniProt (P54619) Pfam (PF00571) In PDB | Homo sapiens (human) | AMPK gamma1, AMPK subunit gamma-1, AMPKg |
| 4 | A | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) | |||
| 5 | G | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 3 | Chemie (AMP) |
Sequence modifications
A: 11 - 550 (UniProt: Q13131)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | Arg 21 | conflict |
| Ser 260 | Thr 269 | conflict |
| Gly 471 | Glu 480 | engineered mutation |
| Ala 474 | Glu 483 | engineered mutation |
| Ala 476 | Lys 485 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118500.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1508.2 | |
| All* | Total formula weight | 120009.0 |
