4RER

Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin

Summary for 4RER

• Entry DOI: 10.2210/pdb4rer/pdb
• Related: 4RED 4REW
• Related PRD ID: PRD_900012
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
• Functional Keywords: human alpha1 beta2 gamma1 holo-ampk complex, serine/threonine protein kinase, axin, camkkbeta, lkb1, glycogen, phosphorylation, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 121560.24

Authors

Zhou, X.E.,Ke, J.,Li, X.,Wang, L.,Gu, X.,de Waal, P.W.,Tan, M.H.E.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K. (deposition date: 2014-09-23, release date: 2014-12-10, Last modification date: 2023-09-20)

• Primary citation: Li, X.,Wang, L.,Zhou, X.E.,Ke, J.,de Waal, P.W.,Gu, X.,Tan, M.H.,Wang, D.,Wu, D.,Xu, H.E.,Melcher, K.; Structural basis of AMPK regulation by adenine nucleotides and glycogen.; Cell Res., 25:50-66, 2015; PubMed: 25412657; DOI: 10.1038/cr.2014.150

Experimental method

X-RAY DIFFRACTION (4.047 Å)