4RER
Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 540 | 61566.1 | 1 | UniProt (Q13131) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) | Homo sapiens (human) | AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1 |
| 2 | B (B) | 5'-AMP-activated protein kinase subunit beta-2 | polymer | 197 | 22449.5 | 1 | UniProt (O43741) Pfam (PF16561) Pfam (PF04739) | Homo sapiens (human) | AMPK subunit beta-2 |
| 3 | C (G) | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 304 | 34645.1 | 1 | UniProt (P54619) Pfam (PF00571) | Homo sapiens (human) | AMPK gamma1, AMPK subunit gamma-1, AMPKg |
| 4 | D (C) | Cycloheptakis-(1-4)-(alpha-D-glucopyranose) | branched | 1153.0 | 1 | In PDB BIRD (PRD_900012) GlyTouCan (G01435GL) | beta-cyclodextrin | ||
| 5 | E (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (5279) PubChem (71203703) PubChem (42610657) PubChem (44259) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (451705) PubChem (73953205) PubChem (86306248) PubChem (358479) PubChem (5280487) PubChem (5459111) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (6419748) PubChem (9804568) PubChem (122130844) PubChem (12046017) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 6 | F (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) PubChem (23831) | |||
| 7 | G, H, I (G) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 3 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) |
Sequence modifications
A: 11 - 550 (UniProt: Q13131)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | Arg 21 | conflict |
| Ser 260 | Thr 269 | conflict |
| Gly 471 | Glu 480 | engineered mutation |
| Ala 474 | Glu 483 | engineered mutation |
| Ala 476 | Lys 485 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118660.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1153.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1746.5 | |
| All* | Total formula weight | 121560.2 |
