2BAJ

p38alpha bound to pyrazolourea

Summary for 2BAJ

Entry DOI	10.2210/pdb2baj/pdb
Related	2BAK 2BAL 2BAQ
Descriptor	Mitogen-activated protein kinase 14, 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea (3 entities in total)
Functional Keywords	mitogen activated protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q16539
Total number of polymer chains	1
Total formula weight	42444.18
Authors	Gerhardt, S.,Pauptit, R.A.,Read, J.,Breed, J.,Norman, R.A.,Ward, W.H. (deposition date: 2005-10-14, release date: 2005-12-06, Last modification date: 2024-02-14)
Primary citation	Sullivan, J.E.,Holdgate, G.A.,Campbell, D.,Timms, D.,Gerhardt, S.,Breed, J.,Breeze, A.L.,Bermingham, A.,Pauptit, R.A.,Norman, R.A.,Embrey, K.J.,Read, J.,Vanscyoc, W.S.,Ward, W.H. Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase Biochemistry, 44:16475-16490, 2005 Cited by PubMed: 16342939 DOI: 10.1021/bi051714v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation