3U2C
 
 | | Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution | | 分子名称: | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, Aldose reductase, CITRIC ACID, ... | | 著者 | Steuber, H. | | 登録日 | 2011-10-03 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | An old NSAID revisited: crystal structure of aldose reductase in complex with sulindac at 1.0 A supports a novel mechanism for its anticancer and antiproliferative effects.
Chemmedchem, 6, 2011
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3T42
 | | Human aldose reductase in complex with a nitrile-containing IDD inhibitor | | 分子名称: | Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Xu, L, Cohen, A.E, Boxer, S.G. | | 登録日 | 2011-07-25 | | 公開日 | 2011-10-05 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Electrostatic Fields near the Active Site of Human Aldose Reductase: 2. New Inhibitors and Complications Caused by Hydrogen Bonds.
Biochemistry, 50, 2011
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3S3G
 | | Crystal Structure of Human Aldose Reductase Complexed with Tolmetin | | 分子名称: | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Tolmetin | | 著者 | Zheng, X, Chen, J, Luo, H, Hu, X. | | 登録日 | 2011-05-18 | | 公開日 | 2012-04-04 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
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3RX3
 | | Crystal Structure of Human Aldose Reductase Complexed with Sulindac | | 分子名称: | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid | | 著者 | Zheng, X, Chen, J, Luo, H, Hu, X. | | 登録日 | 2011-05-10 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
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3RX4
 | | Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide | | 分子名称: | 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]ethanoic acid, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zheng, X, Chen, J, Luo, H, Hu, X. | | 登録日 | 2011-05-10 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.
Febs Lett., 586, 2012
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3RX2
 | | Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone | | 分子名称: | 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]ethanoic acid, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zheng, X, Chen, J, Luo, H, Hu, X. | | 登録日 | 2011-05-10 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase
Febs Lett., 586, 2012
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3R94
 | | AKR1C3 complex with flurbiprofen | | 分子名称: | (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C3, ... | | 著者 | Yosaatmadja, Y, Teague, R.M, Flanagan, J.U, Squire, C.J. | | 登録日 | 2011-03-24 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.013 Å) | | 主引用文献 | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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3R8G
 | | AKR1C3 complex with ibuprofen | | 分子名称: | (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C3, ... | | 著者 | Yosaatmadja, Y, Teague, R.M, Flanagan, J.U, Squire, C.J. | | 登録日 | 2011-03-24 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | | 主引用文献 | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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3R8H
 | | AKR1C3 complex with zomepirac | | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Yosaatmadja, Y, Teague, R.M, Flanagan, J.U, Squire, C.J. | | 登録日 | 2011-03-24 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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3R7M
 | | AKR1C3 complex with sulindac | | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Yosaatmadja, Y, Teague, R.M, Flanagan, J.U, Squire, C.J. | | 登録日 | 2011-03-22 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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3R6I
 | | AKR1C3 complex with meclofenamic acid | | 分子名称: | 1,2-ETHANEDIOL, 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid, Aldo-keto reductase family 1 member C3, ... | | 著者 | Yosaatmadja, Y, Teague, R.M, Flanagan, J.U, Squire, C.J. | | 登録日 | 2011-03-21 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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3R58
 | | AKR1C3 complex with naproxen | | 分子名称: | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C3, ... | | 著者 | Yosaatmadja, Y, Teague, R.M, Flanagan, J.U, Squire, C.J. | | 登録日 | 2011-03-18 | | 公開日 | 2012-03-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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3R43
 | | AKR1C3 complexed with mefenamic acid | | 分子名称: | 1,2-ETHANEDIOL, 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, Aldo-keto reductase family 1 member C3, ... | | 著者 | Squire, C.J, Teague, R.M, Yosaatmadja, L. | | 登録日 | 2011-03-17 | | 公開日 | 2012-03-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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3QKZ
 | | Crystal structure of mutant His269Arg AKR1B14 | | 分子名称: | Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Sundaram, K, El-Kabbani, O. | | 登録日 | 2011-02-02 | | 公開日 | 2012-02-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH.
Acta Crystallogr.,Sect.F, 68, 2012
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3Q65
 | | Human Aldose Reductase in Complex with NADP+ in Space Group P212121 | | 分子名称: | Aldose reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Sawaya, M.R, Cascio, D, Balendiran, G.K. | | 登録日 | 2010-12-30 | | 公開日 | 2011-01-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | The role of Cys-298 in aldose reductase function.
J.Biol.Chem., 286, 2011
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3Q67
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3P2V
 | | Novel Benzothiazepine Inhibitor in Complex with human Aldose Reductase | | 分子名称: | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(2S)-4-oxo-2-phenyl-3,4-dihydro-1,5-benzothiazepin-5(2H)-yl]acetic acid | | 著者 | Koch, C, Heine, A, Klebe, G. | | 登録日 | 2010-10-04 | | 公開日 | 2011-08-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase
Biochim.Biophys.Acta, 1810, 2011
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3ONC
 | | Bond breakage and relocation of a covalently bound bromine of IDD594 in a complex with hAR T113A mutant after moderate radiation dose | | 分子名称: | Aldose reductase, BROMIDE ION, CITRIC ACID, ... | | 著者 | Koch, C, Heine, A, Klebe, G. | | 登録日 | 2010-08-28 | | 公開日 | 2011-08-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | Radiation damage reveals promising interaction position
J.SYNCHROTRON RADIAT., 18, 2011
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3ONB
 | | Bond breakage and relocation of a covalently bound bromine of IDD594 in a complex with hAR T113A mutant after extensive radiation dose | | 分子名称: | Aldose reductase, BROMIDE ION, CITRIC ACID, ... | | 著者 | Koch, C, Heine, A, Klebe, G. | | 登録日 | 2010-08-28 | | 公開日 | 2011-08-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Radiation damage reveals promising interaction position
J.SYNCHROTRON RADIAT., 18, 2011
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3O3R
 | | Crystal Structure of AKR1B14 in complex with NADP | | 分子名称: | Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Sundaram, K, Dhagat, U, El-Kabbani, O. | | 登録日 | 2010-07-26 | | 公開日 | 2011-01-19 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21, 2011
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3O0K
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3NTY
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3N6Q
 | | Crystal structure of YghZ from E. coli | | 分子名称: | MAGNESIUM ION, YghZ aldo-keto reductase | | 著者 | Zubieta, C, Totir, M, Echols, N, May, A, Alber, T. | | 登録日 | 2010-05-26 | | 公開日 | 2011-06-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Macro-to-Micro Structural Proteomics: Native Source Proteins for High-Throughput Crystallization.
Plos One, 7, 2012
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3N2T
 | | Structure of the glycerol dehydrogenase AKR11B4 from Gluconobacter oxydans | | 分子名称: | Putative oxidoreductase | | 著者 | Richter, N, Breicha, K, Hummel, W, Niefind, K. | | 登録日 | 2010-05-19 | | 公開日 | 2010-07-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Three-Dimensional Structure of AKR11B4, a Glycerol Dehydrogenase from Gluconobacter oxydans, Reveals a Tryptophan Residue as an Accelerator of Reaction Turnover.
J.Mol.Biol., 404, 2010
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3MC5
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