3R58

AKR1C3 complex with naproxen

Summary for 3R58

Entry DOI	10.2210/pdb3r58/pdb
Related	3R43 3R6I
Descriptor	Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, ... (5 entities in total)
Functional Keywords	tim barrel, aldo-keto reductase, nitro reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42330
Total number of polymer chains	1
Total formula weight	39199.31
Authors	Yosaatmadja, Y.,Teague, R.M.,Flanagan, J.U.,Squire, C.J. (deposition date: 2011-03-18, release date: 2012-03-28, Last modification date: 2024-02-21)
Primary citation	Flanagan, J.U.,Yosaatmadja, Y.,Teague, R.M.,Chai, M.Z.,Turnbull, A.P.,Squire, C.J. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. Plos One, 7:e43965-e43965, 2012 Cited by PubMed: 22937138 DOI: 10.1371/journal.pone.0043965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation