3RX3
Crystal Structure of Human Aldose Reductase Complexed with Sulindac
Summary for 3RX3
Entry DOI | 10.2210/pdb3rx3/pdb |
Related | 3RX2 3RX4 |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid, ... (4 entities in total) |
Functional Keywords | aldose reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 39169.51 |
Authors | |
Primary citation | Zheng, X.,Zhang, L.,Zhai, J.,Chen, Y.,Luo, H.,Hu, X. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. Febs Lett., 586:55-59, 2012 Cited by PubMed: 22155003DOI: 10.1016/j.febslet.2011.11.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report