3T42
Human aldose reductase in complex with a nitrile-containing IDD inhibitor
Summary for 3T42
| Entry DOI | 10.2210/pdb3t42/pdb |
| Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-chloro-2-[(4-cyano-3-nitrobenzyl)carbamoyl]phenoxy}acetic acid, ... (5 entities in total) |
| Functional Keywords | tim barrel, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P15121 |
| Total number of polymer chains | 1 |
| Total formula weight | 37505.90 |
| Authors | Xu, L.,Cohen, A.E.,Boxer, S.G. (deposition date: 2011-07-25, release date: 2011-10-05, Last modification date: 2023-09-13) |
| Primary citation | Xu, L.,Cohen, A.E.,Boxer, S.G. Electrostatic Fields near the Active Site of Human Aldose Reductase: 2. New Inhibitors and Complications Caused by Hydrogen Bonds. Biochemistry, 50:8311-8322, 2011 Cited by PubMed: 21859105DOI: 10.1021/bi200930f PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
Download full validation report
