Crystal Structure of AKR1B14 in complex with NADP

Summary for 3O3R

DescriptorAldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywordsaldose reductase like protein, akr1b14, oxidoreductase
Biological sourceRattus norvegicus (Rat)
Total number of polymer chains2
Total molecular weight73834.33
Sundaram, K.,Dhagat, U.,El-Kabbani, O. (deposition date: 2010-07-26, release date: 2011-01-19, Last modification date: 2011-07-13)
Primary citation
Sundaram, K.,Dhagat, U.,Endo, S.,Chung, R.,Matsunaga, T.,Hara, A.,El-Kabbani, O.
Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21:801-804, 2011
PubMed: 21168333 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2010.11.086
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2111902.3%8.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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