Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006693 | biological_process | prostaglandin metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0036130 | molecular_function | prostaglandin H2 endoperoxidase reductase activity |
B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
B | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006693 | biological_process | prostaglandin metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0036130 | molecular_function | prostaglandin H2 endoperoxidase reductase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE NAP A 317 |
Chain | Residue |
A | GLY19 |
A | TYR210 |
A | SER211 |
A | PRO212 |
A | LEU213 |
A | GLY214 |
A | SER215 |
A | PRO216 |
A | ASP217 |
A | ALA246 |
A | ILE261 |
A | THR20 |
A | PRO262 |
A | LYS263 |
A | SER264 |
A | VAL265 |
A | THR266 |
A | HIS269 |
A | GLU272 |
A | ASN273 |
A | HOH430 |
A | HOH442 |
A | TRP21 |
A | HOH474 |
A | HOH504 |
A | ASP44 |
A | TYR49 |
A | HIS111 |
A | SER160 |
A | ASN161 |
A | GLN184 |
site_id | AC2 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NAP B 317 |
Chain | Residue |
B | GLY19 |
B | THR20 |
B | TRP21 |
B | LYS22 |
B | ASP44 |
B | TYR49 |
B | HIS111 |
B | SER160 |
B | ASN161 |
B | GLN184 |
B | TYR210 |
B | SER211 |
B | PRO212 |
B | LEU213 |
B | GLY214 |
B | SER215 |
B | PRO216 |
B | ASP217 |
B | ALA246 |
B | ILE261 |
B | PRO262 |
B | LYS263 |
B | SER264 |
B | VAL265 |
B | THR266 |
B | HIS269 |
B | GLU272 |
B | ASN273 |
B | HOH450 |
B | HOH459 |
B | HOH468 |
B | HOH531 |
B | HOH570 |
B | HOH577 |
Functional Information from PROSITE/UniProt
site_id | PS00062 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdqglVKALGVSNF |
Chain | Residue | Details |
A | MET145-PHE162 | |
site_id | PS00798 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHFDCAyvyqnEseVG |
Chain | Residue | Details |
A | GLY39-GLY56 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000250 |
Chain | Residue | Details |
A | TYR49 | |
B | TYR49 | |
Chain | Residue | Details |
A | THR20 | |
B | SER160 | |
B | GLN184 | |
B | TYR210 | |
B | LYS263 | |
B | ASN273 | |
A | ASP44 | |
A | SER160 | |
A | GLN184 | |
A | TYR210 | |
A | LYS263 | |
A | ASN273 | |
B | THR20 | |
B | ASP44 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
Chain | Residue | Details |
A | LYS78 | |
B | LYS78 | |