Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0036130 | molecular_function | prostaglandin H2 endoperoxidase reductase activity |
| B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| B | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0036130 | molecular_function | prostaglandin H2 endoperoxidase reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP A 317 |
| Chain | Residue |
| A | GLY19 |
| A | TYR210 |
| A | SER211 |
| A | PRO212 |
| A | LEU213 |
| A | GLY214 |
| A | SER215 |
| A | PRO216 |
| A | ASP217 |
| A | ALA246 |
| A | ILE261 |
| A | THR20 |
| A | PRO262 |
| A | LYS263 |
| A | SER264 |
| A | VAL265 |
| A | THR266 |
| A | HIS269 |
| A | GLU272 |
| A | ASN273 |
| A | HOH430 |
| A | HOH442 |
| A | TRP21 |
| A | HOH474 |
| A | HOH504 |
| A | ASP44 |
| A | TYR49 |
| A | HIS111 |
| A | SER160 |
| A | ASN161 |
| A | GLN184 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAP B 317 |
| Chain | Residue |
| B | GLY19 |
| B | THR20 |
| B | TRP21 |
| B | LYS22 |
| B | ASP44 |
| B | TYR49 |
| B | HIS111 |
| B | SER160 |
| B | ASN161 |
| B | GLN184 |
| B | TYR210 |
| B | SER211 |
| B | PRO212 |
| B | LEU213 |
| B | GLY214 |
| B | SER215 |
| B | PRO216 |
| B | ASP217 |
| B | ALA246 |
| B | ILE261 |
| B | PRO262 |
| B | LYS263 |
| B | SER264 |
| B | VAL265 |
| B | THR266 |
| B | HIS269 |
| B | GLU272 |
| B | ASN273 |
| B | HOH450 |
| B | HOH459 |
| B | HOH468 |
| B | HOH531 |
| B | HOH570 |
| B | HOH577 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdqglVKALGVSNF |
| Chain | Residue | Details |
| A | MET145-PHE162 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHFDCAyvyqnEseVG |
| Chain | Residue | Details |
| A | GLY39-GLY56 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR49 | |
| B | TYR49 | |
| Chain | Residue | Details |
| A | THR20 | |
| B | SER160 | |
| B | GLN184 | |
| B | TYR210 | |
| B | LYS263 | |
| B | ASN273 | |
| A | ASP44 | |
| A | SER160 | |
| A | GLN184 | |
| A | TYR210 | |
| A | LYS263 | |
| A | ASN273 | |
| B | THR20 | |
| B | ASP44 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS78 | |
| B | LYS78 | |
