3Q65

Human Aldose Reductase in Complex with NADP+ in Space Group P212121

Summary for 3Q65

• Entry DOI: 10.2210/pdb3q65/pdb
• Related: 3Q67
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (5 entities in total)
• Functional Keywords: alpha/beta barrel, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 2
• Total formula weight: 74240.15

Authors

Sawaya, M.R.,Cascio, D.,Balendiran, G.K. (deposition date: 2010-12-30, release date: 2011-01-19, Last modification date: 2024-02-21)

• Primary citation: Balendiran, G.K.,Sawaya, M.R.,Schwarz, F.P.,Ponniah, G.,Cuckovich, R.,Verma, M.,Cascio, D.; The role of Cys-298 in aldose reductase function.; J.Biol.Chem., 286:6336-6344, 2011; PubMed: 21084309; DOI: 10.1074/jbc.M110.154195

Experimental method

X-RAY DIFFRACTION (2.09 Å)