6YYW
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![BU of 6yyw by Molmil](/molmil-images/mine/6yyw) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser) | 分子名称: | 2-OXOGLUTARIC ACID, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2020-05-06 | 公開日 | 2021-03-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase. Chem Sci, 12, 2020
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6YYX
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![BU of 6yyx by Molmil](/molmil-images/mine/6yyx) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-methyl-2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser) | 分子名称: | (3~{R})-3-methyl-2-oxidanylidene-pentanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2020-05-06 | 公開日 | 2021-03-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase Chem Sci, 12, 2021
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6YYY
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![BU of 6yyy by Molmil](/molmil-images/mine/6yyy) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 4,4-dimethyl-2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser) | 分子名称: | 2,2-dimethyl-4-oxidanylidene-pentanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2020-05-06 | 公開日 | 2021-03-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase. Chem Sci, 12, 2020
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6Z6Q
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![BU of 6z6q by Molmil](/molmil-images/mine/6z6q) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-ethyl-2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser) | 分子名称: | (3~{R})-3-ethyl-2-oxidanylidene-pentanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2020-05-29 | 公開日 | 2021-03-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase. Chem Sci, 12, 2020
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6Z6R
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![BU of 6z6r by Molmil](/molmil-images/mine/6z6r) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, N-oxalyl-alpha-methylalanine, and factor X substrate peptide fragment(39mer-4Ser) | 分子名称: | Aspartyl/asparaginyl beta-hydroxylase, BROMIDE ION, Coagulation factor X, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2020-05-29 | 公開日 | 2021-03-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase. Chem Sci, 12, 2020
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7ALJ
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![BU of 7alj by Molmil](/molmil-images/mine/7alj) | Structure of Drosophila Notch EGF domains 11-13 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus Notch protein, ... | 著者 | Suckling, R, Johnson, S, Lea, S.M. | 登録日 | 2020-10-06 | 公開日 | 2021-08-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling. Embo Rep., 22, 2021
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7BMI
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![BU of 7bmi by Molmil](/molmil-images/mine/7bmi) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) | 分子名称: | 3-fluoranylpyridine-2,4-dicarboxylic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2021-01-20 | 公開日 | 2021-06-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases J Fluor Chem, 247, 2021
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7BMJ
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![BU of 7bmj by Molmil](/molmil-images/mine/7bmj) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 5-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) | 分子名称: | 5-fluoranylpyridine-2,4-dicarboxylic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2021-01-20 | 公開日 | 2021-06-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases J Fluor Chem, 247, 2021
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7E6J
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![BU of 7e6j by Molmil](/molmil-images/mine/7e6j) | Aspartyl/Asparaginyl beta-hydroxylase (AspH) H725A in complex with Factor X peptide fragment (39mer-4Ser) | 分子名称: | Aspartyl/asparaginyl beta-hydroxylase, GLYCEROL, PROPANOIC ACID, ... | 著者 | Nakashima, Y, Brasnett, A, Brewitz, L, Schofield, C.J. | 登録日 | 2021-02-22 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active. Angew.Chem.Int.Ed.Engl., 60, 2021
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7MN8
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![BU of 7mn8 by Molmil](/molmil-images/mine/7mn8) | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | 登録日 | 2021-04-30 | 公開日 | 2021-11-10 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021
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7OM4
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![BU of 7om4 by Molmil](/molmil-images/mine/7om4) | |
7QAB
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![BU of 7qab by Molmil](/molmil-images/mine/7qab) | |
7SYD
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![BU of 7syd by Molmil](/molmil-images/mine/7syd) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SYE
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![BU of 7sye by Molmil](/molmil-images/mine/7sye) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ0
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![BU of 7sz0 by Molmil](/molmil-images/mine/7sz0) | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ1
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![BU of 7sz1 by Molmil](/molmil-images/mine/7sz1) | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7TPP
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![BU of 7tpp by Molmil](/molmil-images/mine/7tpp) | |
7TPQ
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![BU of 7tpq by Molmil](/molmil-images/mine/7tpq) | |
7YB8
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![BU of 7yb8 by Molmil](/molmil-images/mine/7yb8) | |
7YB9
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![BU of 7yb9 by Molmil](/molmil-images/mine/7yb9) | |
7YBB
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![BU of 7ybb by Molmil](/molmil-images/mine/7ybb) | |
7YBC
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![BU of 7ybc by Molmil](/molmil-images/mine/7ybc) | |
8CN9
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![BU of 8cn9 by Molmil](/molmil-images/mine/8cn9) | |
8D1B
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![BU of 8d1b by Molmil](/molmil-images/mine/8d1b) | |
8EOK
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![BU of 8eok by Molmil](/molmil-images/mine/8eok) | |