7BMI

Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser)

Summary for 7BMI

• Entry DOI: 10.2210/pdb7bmi/pdb
• Descriptor: Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: aspartyl/asparaginyl beta-hydroxylase, dioxygenase, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 53835.77

Authors

Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2021-01-20, release date: 2021-06-02, Last modification date: 2024-01-31)

• Primary citation: Brewitz, L.,Nakashima, Y.,Tumber, A.,Salah, E.,Schofield, C.J.; Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases; J Fluor Chem, 247:109804-, 2021; DOI: 10.1016/j.jfluchem.2021.109804

Experimental method

X-RAY DIFFRACTION (1.66 Å)