3E8K
 
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3DSC
 | | Crystal structure of P. furiosus Mre11 DNA synaptic complex | | 分子名称: | DNA (5'-D(P*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DAP*DC)-3'), DNA double-strand break repair protein mre11 | | 著者 | Williams, R.S, Moncalian, G, Shin, D.S, Tainer, J.A. | | 登録日 | 2008-07-11 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Cell(Cambridge,Mass.), 135, 2008
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3DAB
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4RQI
 | | Structure of TRF2/RAP1 secondary interaction binding site | | 分子名称: | GLYCEROL, MAGNESIUM ION, Telomeric repeat-binding factor 2, ... | | 著者 | Miron, S, Guimaraes, B, Gaullier, G, Giraud-Panis, M.-J, Gilson, E, Le Du, M.-H. | | 登録日 | 2014-11-03 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4405 Å) | | 主引用文献 | A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
Nucleic Acids Res., 44, 2016
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1HJ3
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1IH9
 | | NMR Structure of Zervamicin IIB (peptaibol antibiotic) Bound to DPC Micelles | | 分子名称: | ZERVAMICIN IIB | | 著者 | Shenkarev, Z.O, Balasheva, T.A, Efremov, R.G, Yakimenko, Z.A, Ovchinnikova, T.V, Raap, J, Arseniev, A.S. | | 登録日 | 2001-04-19 | | 公開日 | 2002-02-13 | | 最終更新日 | 2012-12-12 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Spatial Structure of Zervamicin Iib Bound to Dpc Micelles: Implications for Voltage-Gating.
Biophys.J., 82, 2002
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2DKH
 | | Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni, in complex with the substrate | | 分子名称: | 3-HYDROXYBENZOIC ACID, 3-hydroxybenzoate hydroxylase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Hiromoto, T, Fujiwara, S, Hosokawa, K, Yamaguchi, H. | | 登録日 | 2006-04-11 | | 公開日 | 2006-10-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni has a large tunnel for substrate and oxygen access to the active site
J.Mol.Biol., 364, 2006
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5GOX
 | | Eukaryotic Rad50 Functions as A Rod-shaped Dimer | | 分子名称: | DNA repair protein RAD50, GLYCEROL, ZINC ION | | 著者 | Park, Y.B, Hohl, M, Padjasek, M, Jeong, E, Jin, K.S, Krezel, A, Petrini, J.H.J, Cho, Y. | | 登録日 | 2016-07-30 | | 公開日 | 2017-02-01 | | 最終更新日 | 2017-03-15 | | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | | 主引用文献 | Eukaryotic Rad50 functions as a rod-shaped dimer
Nat. Struct. Mol. Biol., 24, 2017
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1HJ5
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1HJ4
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5HPD
 | | Solution Structure of TAZ2-p53TAD | | 分子名称: | CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION | | 著者 | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | | 登録日 | 2016-01-20 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5HOU
 | | Solution Structure of p53TAD-TAZ1 | | 分子名称: | Cellular tumor antigen p53,CREB-binding protein fusion protein, ZINC ION | | 著者 | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | | 登録日 | 2016-01-19 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
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1LB7
 | | IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1 | | 分子名称: | IGF-1 ANTAGONIST F1-1 | | 著者 | Deshayes, K, Schaffer, M.L, Skelton, N.J, Nakamura, G.R, Kadkhodayan, S, Sidhu, S.S. | | 登録日 | 2002-04-02 | | 公開日 | 2002-06-19 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function.
Chem.Biol., 9, 2002
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5GHD
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2AZM
 | | Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX | | 分子名称: | GAMMA-H2AX HISTONE, Mediator of DNA damage checkpoint protein 1 | | 著者 | Clapperton, J.A, Stucki, M, Mohammad, D, Yaffe, M.B, Jackson, S.P, Smerdon, S.J. | | 登録日 | 2005-09-12 | | 公開日 | 2006-01-31 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Cell(Cambridge,Mass.), 123, 2005
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6Z1C
 | | Crystal structure of Arabidopsis thaliana CK2-alpha-1 in complex with TTP-22 | | 分子名称: | 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha-1 | | 著者 | Demulder, M, Loris, R, De Veylder, L. | | 登録日 | 2020-05-13 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
Plant Cell, 33, 2021
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8R1G
 | | Dimeric ternary structure of E6AP-E6-p53 | | 分子名称: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | | 著者 | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | | 登録日 | 2023-11-01 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | | 主引用文献 | Monomeric E6AP-E6-p53 ternary complex
To Be Published
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8R1F
 | | Monomeric E6AP-E6-p53 ternary complex | | 分子名称: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | | 著者 | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | | 登録日 | 2023-11-01 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Monomeric E6AP-E6-p53 ternary complex
To Be Published
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8R62
 | | Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition | | 分子名称: | 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-1~{H}-pyrido[1,2-a]pyrimidin-4-one, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') | | 著者 | Malard, F, Campagne, S. | | 登録日 | 2023-11-20 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Nucleic Acids Res., 52, 2024
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4GAC
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6ZWK
 | | Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) | | 分子名称: | CHLORIDE ION, Histone H2AX, SODIUM ION, ... | | 著者 | McEwen, A.G, Moeglin, E, Desplancq, D, Weiss, E, Poterszman, A. | | 登録日 | 2020-07-28 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress.
Cancers (Basel), 13, 2021
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7AI0
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7AI1
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7AKH
 | | Structure of DYRK2 in complex with compound 58 | | 分子名称: | 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | | 著者 | Dokurno, P, Surgenor, A.E, Kotschy, A. | | 登録日 | 2020-10-01 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
J.Med.Chem., 64, 2021
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7AKF
 | | Structure of DYRK2 in complex with compound 50 | | 分子名称: | 4-(2,3-dimethyl-1-benzofuran-5-yl)pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | | 著者 | Dokurno, P, Surgenor, A.E, Kotschy, A. | | 登録日 | 2020-09-30 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
J.Med.Chem., 64, 2021
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