6TCZ

Leishmania tarentolae proteasome 20S subunit complexed with LXE408

Summary for 6TCZ

• Entry DOI: 10.2210/pdb6tcz/pdb
• EMDB information: 10462
• Descriptor: Proteasome subunit alpha type, Proteasome subunit beta, Proteasome subunit family protein, ... (15 entities in total)
• Functional Keywords: proteasome complex, inhibitor, peptidase, hydrolase
• Biological source: Leishmania donovani; More
• Total number of polymer chains: 28
• Total formula weight: 848731.37

Authors

Srinivas, H. (deposition date: 2019-11-07, release date: 2020-08-26, Last modification date: 2020-10-21)

• Primary citation: Nagle, A.,Biggart, A.,Be, C.,Srinivas, H.,Hein, A.,Caridha, D.,Sciotti, R.J.,Pybus, B.,Kreishman-Deitrick, M.,Bursulaya, B.,Lai, Y.H.,Gao, M.Y.,Liang, F.,Mathison, C.J.N.,Liu, X.,Yeh, V.,Smith, J.,Lerario, I.,Xie, Y.,Chianelli, D.,Gibney, M.,Berman, A.,Chen, Y.L.,Jiricek, J.,Davis, L.C.,Liu, X.,Ballard, J.,Khare, S.,Eggimann, F.K.,Luneau, A.,Groessl, T.,Shapiro, M.,Richmond, W.,Johnson, K.,Rudewicz, P.J.,Rao, S.P.S.,Thompson, C.,Tuntland, T.,Spraggon, G.,Glynne, R.J.,Supek, F.,Wiesmann, C.,Molteni, V.; Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.; J.Med.Chem., 63:10773-10781, 2020; PubMed: 32667203; DOI: 10.1021/acs.jmedchem.0c00499

Experimental method

ELECTRON MICROSCOPY (3.4 Å)