6TCZ

Leishmania tarentolae proteasome 20S subunit complexed with LXE408

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016787	molecular_function	hydrolase activity
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016787	molecular_function	hydrolase activity
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0016787	molecular_function	hydrolase activity
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0005839	cellular_component	proteasome core complex
K	0010498	biological_process	proteasomal protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0006508	biological_process	proteolysis
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
a	0000502	cellular_component	proteasome complex
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0016787	molecular_function	hydrolase activity
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0051603	biological_process	proteolysis involved in protein catabolic process
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0051603	biological_process	proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0016787	molecular_function	hydrolase activity
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0051603	biological_process	proteolysis involved in protein catabolic process
g	0000502	cellular_component	proteasome complex
g	0005634	cellular_component	nucleus
g	0005737	cellular_component	cytoplasm
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0016787	molecular_function	hydrolase activity
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0051603	biological_process	proteolysis involved in protein catabolic process
h	0000502	cellular_component	proteasome complex
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005839	cellular_component	proteasome core complex
h	0051603	biological_process	proteolysis involved in protein catabolic process
i	0000502	cellular_component	proteasome complex
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005634	cellular_component	nucleus
i	0005737	cellular_component	cytoplasm
i	0005839	cellular_component	proteasome core complex
i	0051603	biological_process	proteolysis involved in protein catabolic process
j	0000502	cellular_component	proteasome complex
j	0005634	cellular_component	nucleus
j	0005737	cellular_component	cytoplasm
j	0005839	cellular_component	proteasome core complex
j	0016787	molecular_function	hydrolase activity
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	proteolysis involved in protein catabolic process
k	0005839	cellular_component	proteasome core complex
k	0010498	biological_process	proteasomal protein catabolic process
k	0051603	biological_process	proteolysis involved in protein catabolic process
l	0000502	cellular_component	proteasome complex
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005634	cellular_component	nucleus
l	0005737	cellular_component	cytoplasm
l	0005839	cellular_component	proteasome core complex
l	0006508	biological_process	proteolysis
l	0051603	biological_process	proteolysis involved in protein catabolic process
m	0000502	cellular_component	proteasome complex
m	0005634	cellular_component	nucleus
m	0005737	cellular_component	cytoplasm
m	0005839	cellular_component	proteasome core complex
m	0051603	biological_process	proteolysis involved in protein catabolic process
n	0000502	cellular_component	proteasome complex
n	0005634	cellular_component	nucleus
n	0005737	cellular_component	cytoplasm
n	0005839	cellular_component	proteasome core complex
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue N2E L 401

Chain	Residue
K	PHE24
L	GLY228
L	SER229
L	SER231
L	TYR235
K	ILE29
L	THR100
L	SER120
L	SER195
L	TYR212
L	ASP214
L	PHE225
L	VAL227

---

site_id	AC2
Number of Residues	13
Details	binding site for residue N2E l 401

Chain	Residue
k	PHE24
l	THR100
l	SER120
l	GLY122
l	GLY146
l	SER195
l	GLY197
l	TYR212
l	SER226
l	VAL227
l	SER229
l	SER231
l	TYR235

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Functional Information from PROSITE/UniProt

site_id	PS00300
Number of Residues	14
Details	SRP54 SRP54-type proteins GTP-binding domain signature. PImFTSKSEyDrgV

Chain	Residue	Details
E	PRO99-VAL112

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site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. FdkyiTvFSPeGSlyQVEYAfkA

Chain	Residue	Details
A	PHE6-ALA28
D	TYR3-ALA25
C	TYR5-ALA27
E	TYR108-ALA130
B	ALA4-ALA26
F	TYR170-ALA192

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVvYrdGVVLGADtrategsivadkrcr.KihymapnimccgaGtsAD

Chain	Residue	Details
I	VAL33-ASP80
J	MET12-ASP59
H	LEU58-ASP105
n	ILE8-ASP55
L	LEU103-ASP150
m	ALA137-ASP185

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