8PFI

Crystal structure of human TLR8 in complex with compound 34

Summary for 8PFI

Entry DOI	10.2210/pdb8pfi/pdb
Descriptor	Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	tlr8, toll-like receptor, immune, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	193151.76
Authors	Faller, M.,Zink, F. (deposition date: 2023-06-16, release date: 2023-08-16, Last modification date: 2023-08-30)
Primary citation	Alper, P.,Betschart, C.,Andre, C.,Boulay, T.,Cheng, D.,Deane, J.,Faller, M.,Feifel, R.,Glatthar, R.,Han, D.,Hemmig, R.,Jiang, T.,Knoepfel, T.,Maginnis, J.,Mutnick, D.,Pei, W.,Ruzzante, G.,Syka, P.,Zhang, G.,Zhang, Y.,Zink, F.,Zipfel, G.,Hawtin, S.,Junt, T.,Michellys, P.Y. Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases. Acs Med.Chem.Lett., 14:1054-1062, 2023 Cited by PubMed: 37583811 DOI: 10.1021/acsmedchemlett.3c00136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.785 Å)

Structure validation