8PFI
Crystal structure of human TLR8 in complex with compound 34
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 8 | polymer | 807 | 92307.8 | 2 | UniProt (Q9NR97) Pfam (PF13855) | Homo sapiens (human) | |
| 2 | C, E, F, H (C, E, F, H) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
| 3 | D, G (D, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | I, J, K, L, M... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
| 5 | O, P (A, B) | (3~{S})-~{N}-[4-[[5-(1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-3-methyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-1-yl]methyl]-1-bicyclo[2.2.2]octanyl]morpholine-3-carboxamide | non-polymer | 532.7 | 2 | Chemie (YHG) | |||
| 6 | W, X (A, B) | water | water | 18.0 | 498 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 827 (UniProt: Q9NR97)
| PDB | External Database | Details |
|---|---|---|
| Glu 828 | - | expression tag |
| Phe 829 | - | expression tag |
| Leu 830 | - | expression tag |
| Val 831 | - | expression tag |
| Pro 832 | - | expression tag |
| Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 184615.5 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 4816.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3719.9 | |
| All* | Total formula weight | 193151.8 |
