8PFI
Crystal structure of human TLR8 in complex with compound 34
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002224 | biological_process | toll-like receptor signaling pathway |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1600 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU27-THR827 | |
| B | GLU27-THR827 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN29 | |
| A | ASN443 | |
| A | ASN582 | |
| A | ASN752 | |
| B | ASN29 | |
| B | ASN42 | |
| B | ASN115 | |
| B | ASN160 | |
| B | ASN247 | |
| B | ASN285 | |
| B | ASN358 | |
| A | ASN42 | |
| B | ASN362 | |
| B | ASN416 | |
| B | ASN443 | |
| B | ASN582 | |
| B | ASN752 | |
| A | ASN115 | |
| A | ASN160 | |
| A | ASN247 | |
| A | ASN285 | |
| A | ASN358 | |
| A | ASN362 | |
| A | ASN416 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN80 | |
| A | ASN88 | |
| B | ASN80 | |
| B | ASN88 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 |
| Chain | Residue | Details |
| A | ASN293 | |
| B | ASN511 | |
| B | ASN546 | |
| B | ASN590 | |
| B | ASN640 | |
| B | ASN680 | |
| A | ASN395 | |
| A | ASN511 | |
| A | ASN546 | |
| A | ASN590 | |
| A | ASN640 | |
| A | ASN680 | |
| B | ASN293 | |
| B | ASN395 |
