4HZE

Crystal structure of human Arginase-2 complexed with inhibitor 9

Summary for 4HZE

• Entry DOI: 10.2210/pdb4hze/pdb
• Related: 1D3V 1PQ3 4HWW 4HXQ
• Descriptor: Arginase-2, mitochondrial, MANGANESE (II) ION, BENZAMIDINE, ... (6 entities in total)
• Functional Keywords: metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, mitochondrion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion : P78540
• Total number of polymer chains: 3
• Total formula weight: 101763.40

Authors

Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.,Zhang, M.,Beckett, P.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,Schroeter, H.,Van Zandt, M.C.,Podjarny, A. (deposition date: 2012-11-15, release date: 2013-03-20, Last modification date: 2023-09-20)

• Primary citation: Van Zandt, M.C.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.K.,Zhang, M.,Beckett, R.P.,Jagdmann, G.E.,Ryder, T.R.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,D'Angelo, G.,Mitschler, A.,Cousido-Siah, A.,Ruiz, F.X.,Howard, E.I.,Podjarny, A.D.,Schroeter, H.; Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.; J.Med.Chem., 56:2568-2580, 2013; PubMed: 23472952; DOI: 10.1021/jm400014c

Experimental method

X-RAY DIFFRACTION (1.602 Å)