4HWW

Crystal structure of human Arginase-1 complexed with inhibitor 9

Summary for 4HWW

Entry DOI	10.2210/pdb4hww/pdb
Related	1D3V 2AEB 4HXQ 4HZE
Descriptor	Arginase-1, [(5R)-5-amino-5-carboxy-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-), MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P05089
Total number of polymer chains	2
Total formula weight	68673.80
Authors	Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.,Zhang, M.,Beckett, P.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,Schroeter, H.,Van Zandt, M.C.,Podjarny, A. (deposition date: 2012-11-09, release date: 2013-03-20, Last modification date: 2023-09-20)
Primary citation	Van Zandt, M.C.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.K.,Zhang, M.,Beckett, R.P.,Jagdmann, G.E.,Ryder, T.R.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,D'Angelo, G.,Mitschler, A.,Cousido-Siah, A.,Ruiz, F.X.,Howard, E.I.,Podjarny, A.D.,Schroeter, H. Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury. J.Med.Chem., 56:2568-2580, 2013 Cited by PubMed: 23472952 DOI: 10.1021/jm400014c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.298 Å)

Structure validation