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4WZ8

Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6

Summary for 4WZ8
Entry DOI10.2210/pdb4wz8/pdb
Related4WYO
DescriptorAcetyl-CoA carboxylase, 1'-(2H-indazol-5-ylcarbonyl)-1-(propan-2-yl)-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one (3 entities in total)
Functional Keywordsacc, acetyl-coa, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm: Q00955
Total number of polymer chains2
Total formula weight175224.62
Authors
Vajdos, F.F. (deposition date: 2014-11-18, release date: 2014-12-10, Last modification date: 2024-02-28)
Primary citationGriffith, D.A.,Kung, D.W.,Esler, W.P.,Amor, P.A.,Bagley, S.W.,Beysen, C.,Carvajal-Gonzalez, S.,Doran, S.D.,Limberakis, C.,Mathiowetz, A.M.,McPherson, K.,Price, D.A.,Ravussin, E.,Sonnenberg, G.E.,Southers, J.A.,Sweet, L.J.,Turner, S.M.,Vajdos, F.F.
Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.
J.Med.Chem., 57:10512-10526, 2014
Cited by
PubMed: 25423286
DOI: 10.1021/jm5016022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.23 Å)
Structure validation

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