Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 20 件
1ZUC
DownloadVisualize
BU of 1zuc by Molmil
Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget
分子名称: 5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE, Progesterone receptor, SULFATE ION
著者Zhang, Z, Olland, A.M, Zhu, Y, Cohen, J, Berrodin, T, Chippari, S, Appavu, C, Li, S, Wilhem, J, Chopra, R, Fensome, A, Zhang, P, Wrobel, J, Unwalla, R.J, Lyttle, C.R, Winneker, R.C.
登録日2005-05-30
公開日2005-07-05
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget
J.Biol.Chem., 280, 2005
5CC0
DownloadVisualize
BU of 5cc0 by Molmil
AncSR2 - TSLP nGRE complex
分子名称: AncSR2 DNA Binding Domain, DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), ...
著者Hudson, W.H, Ortlund, E.A.
登録日2015-07-01
公開日2015-12-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
2W8Y
DownloadVisualize
BU of 2w8y by Molmil
RU486 bound to the progesterone receptor in a destabilized agonistic conformation
分子名称: (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one, 1,2-ETHANEDIOL, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, ...
著者Raaijmakers, H.C.A, Versteeg, J, Uitdehaag, J.C.M.
登録日2009-01-20
公開日2009-04-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.
J.Biol.Chem., 284, 2009
2C7A
DownloadVisualize
BU of 2c7a by Molmil
STRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX
分子名称: 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*AP*AP *CP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*TP *TP*TP*GP*TP*TP*CP*TP*G)-3', PROGESTERONE RECEPTOR, ...
著者Roemer, S.C, Donham, D.C, Sherman, L, Pon, V.H, Edwards, D.P, Churchill, M.E.A.
登録日2005-11-19
公開日2006-08-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Progesterone Receptor-Deoxyribonucleic Acid Complex: Novel Interactions Required for Binding to Half-Site Response Elements.
Mol.Endocrinol., 20, 2006
3D90
DownloadVisualize
BU of 3d90 by Molmil
Crystal structure of the human progesterone receptor ligand-binding domain bound to levonorgestrel
分子名称: 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE, Progesterone receptor
著者Petit-Topin, I, Turque, N, Ulman, A, Gainer, E, Rafestin-Oblin, M.E, Fagart, J.
登録日2008-05-26
公開日2009-05-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins
Mol.Pharmacol., 75, 2009
2OVM
DownloadVisualize
BU of 2ovm by Molmil
Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor NCoR
分子名称: 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, NCoR, Progesterone receptor
著者Madauss, K.P, Deng, S.-J, Short, S.A, Stewart, E.L, Williams, S.P.
登録日2007-02-14
公開日2007-03-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Mol.Endocrinol., 21, 2007
3HQ5
DownloadVisualize
BU of 3hq5 by Molmil
Progesterone Receptor bound to an Alkylpyrrolidine ligand.
分子名称: 2-chloro-4-{[(3S)-1-methylpyrrolidin-3-yl][2-(trifluoromethyl)benzyl]amino}benzonitrile, GLYCEROL, Progesterone receptor, ...
著者Madauss, K.P, Williams, S.P, Washburn, D.G.
登録日2009-06-05
公開日2010-03-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Bioorg.Med.Chem.Lett., 19, 2009
2OVH
DownloadVisualize
BU of 2ovh by Molmil
Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT
分子名称: 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, Progesterone receptor, SMRT peptide
著者Madauss, K.P, Deng, S.-J, Short, S.A, Stewart, E.L, Williams, S.P.
登録日2007-02-13
公開日2007-03-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Mol.Endocrinol., 21, 2007
1E3K
DownloadVisualize
BU of 1e3k by Molmil
Human Progesteron Receptor Ligand Binding Domain in complex with the ligand metribolone (R1881)
分子名称: (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE, PROGESTERONE RECEPTOR
著者Matias, P.M, Donner, P, Coelho, R, Thomaz, M, Peixoto, C, Macedo, S, Otto, N, Joschko, S, Scholz, P, Wegg, A, Basler, S, Schafer, M, Egner, U, Carrondo, M.A.
登録日2000-06-19
公開日2001-06-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.
J. Biol. Chem., 275, 2000
3KBA
DownloadVisualize
BU of 3kba by Molmil
Progesterone receptor bound to sulfonamide pyrrolidine partial agonist
分子名称: 2-chloro-4-{(2-methylbenzyl)[(3S)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}benzonitrile, Progesterone receptor, SULFATE ION
著者Kallander, L.S, Washburn, D.G, Williams, S.P, Madauss, K.P.
登録日2009-10-20
公開日2009-12-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Bioorg.Med.Chem.Lett., 20, 2010
1SR7
DownloadVisualize
BU of 1sr7 by Molmil
Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate
分子名称: GLYCEROL, MOMETASONE FUROATE, Progesterone receptor, ...
著者Madauss, K.P, Deng, S.-J, Austin, R.J, Lambert, M.H, McLay, I, Pritchard, J, Short, S.A, Stewart, E.L, Uings, I.J, Williams, S.P.
登録日2004-03-22
公開日2004-06-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes
J.Med.Chem., 47, 2004
1SQN
DownloadVisualize
BU of 1sqn by Molmil
Progesterone Receptor Ligand Binding Domain with bound Norethindrone
分子名称: (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one, progesterone receptor
著者Williams, S.P, Madauss, K.P, Deng, J.-S, Austin, R.J.H, Lambert, M.H, McLay, I, Pritchard, J, Short, S.A, Stewart, E.L, Uings, I.J.
登録日2004-03-19
公開日2004-07-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.451 Å)
主引用文献Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes
J.Med.Chem., 47, 2004
3G8O
DownloadVisualize
BU of 3g8o by Molmil
Progesterone Receptor with bound Pyrrolidine 1
分子名称: N~2~-[4-cyano-3-(trifluoromethyl)phenyl]-N,N-dimethyl-N~2~-(2,2,2-trifluoroethyl)-L-alaninamide, Progesterone receptor, SULFATE ION
著者Thompson, S.K, Washburn, D.G, Madauss, K.P, Williams, S.P, Stewart, E.L.
登録日2009-02-12
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Bioorg.Med.Chem.Lett., 19, 2009
1A28
DownloadVisualize
BU of 1a28 by Molmil
HORMONE-BOUND HUMAN PROGESTERONE RECEPTOR LIGAND-BINDING DOMAIN
分子名称: PROGESTERONE, PROGESTERONE RECEPTOR
著者Sigler, P.B, Williams, S.P.
登録日1998-01-19
公開日1998-07-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Atomic structure of progesterone complexed with its receptor.
Nature, 393, 1998
3ZR7
DownloadVisualize
BU of 3zr7 by Molmil
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators
分子名称: 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, GLYCEROL, PROGESTERONE RECEPTOR, ...
著者Lusher, S.J, Raaijmakers, H.C.A, Vu-Pham, D, Dechering, K, Wai Lam, T, Brown, A.R, Hamilton, N.M, Nimz, O, Azevedo, R, McGuire, R, Oubrie, A, de Vlieg, J.
登録日2011-06-15
公開日2011-08-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.
J. Biol. Chem., 286, 2011
3ZRB
DownloadVisualize
BU of 3zrb by Molmil
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators
分子名称: (R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, GLYCEROL, ...
著者Lusher, S.J, Raaijmakers, H.C.A, Vu-Pham, D, Dechering, K, Wai Lam, T, Brown, A.R, Hamilton, N.M, Nimz, O, Azevedo, R, Mcguire, R, Oubrie, A, de Vlieg, J.
登録日2011-06-15
公開日2011-08-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.
J. Biol. Chem., 286, 2011
3ZRA
DownloadVisualize
BU of 3zra by Molmil
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators
分子名称: N-{(1R)-1-[4-(2-CHLORO-5-FLUOROPYRIDIN-3-YL)PHENYL]ETHYL}-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE, PROGESTERONE RECEPTOR, SULFATE ION
著者Lusher, S.J, Raaijmakers, H.C.A, Vu-Pham, D, Dechering, K, Wai Lam, T, Brown, A.R, Hamilton, N.M, Nimz, O, Azevedo, R, McGuire, R, Oubrie, A, de Vlieg, J.
登録日2011-06-15
公開日2011-08-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.
J. Biol. Chem., 286, 2011
4A2J
DownloadVisualize
BU of 4a2j by Molmil
PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids
分子名称: 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, PROGESTERONE RECEPTOR, SULFATE ION
著者Lusher, S.J, Raaijmakers, H.C.A, Bosch, R, Vu-Pham, D, McGuire, R, Oubrie, A, de Vlieg, J.
登録日2011-09-27
公開日2012-04-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11 beta-substituted steroids.
J. Biol. Chem., 287, 2012
4APU
DownloadVisualize
BU of 4apu by Molmil
PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids
分子名称: (8S,11R,13S,14S,16S,17S)-17-cyclopropylcarbonyl-16-ethenyl-13-methyl-11-(4-pyridin-3-ylphenyl)-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, PROGESTERONE RECEPTOR, ...
著者Lusher, S.J, Raaijmakers, H.C.A, Bosch, R, Vu-Pham, D, McGuire, R, Oubrie, A, de Vlieg, J.
登録日2012-04-06
公開日2012-04-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11 beta-substituted steroids.
J. Biol. Chem., 287, 2012
4OAR
DownloadVisualize
BU of 4oar by Molmil
Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT
分子名称: Peptide from Nuclear receptor corepressor 2, Progesterone receptor, [(8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopen ta[a]phenanthren-17-yl] acetate
著者Petit-Topin, I, Fay, M.R, Resche-Rigon, M, Ulmann, A, Gainer, E, Rafestin-Oblin, M.-E, Fagart, J.
登録日2014-01-06
公開日2014-10-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors.
J.Steroid Biochem.Mol.Biol., 144PB, 2014

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon