4APU

PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids

Summary for 4APU

Entry DOI	10.2210/pdb4apu/pdb
Related	1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2W8Y 3ZR7 3ZRA 3ZRB 4A2J
Descriptor	PROGESTERONE RECEPTOR, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, SULFATE ION, ... (5 entities in total)
Functional Keywords	transcription, asoprisnil, partial agonist
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
Total number of polymer chains	2
Total formula weight	60930.81
Authors	Lusher, S.J.,Raaijmakers, H.C.A.,Bosch, R.,Vu-Pham, D.,McGuire, R.,Oubrie, A.,de Vlieg, J. (deposition date: 2012-04-06, release date: 2012-04-25, Last modification date: 2023-12-20)
Primary citation	Lusher, S.J.,Raaijmakers, H.C.,Vu-Pham, D.,Kazemier, B.,Bosch, R.,McGuire, R.,Azevedo, R.,Hamersma, H.,Dechering, K.,Oubrie, A.,van Duin, M.,de Vlieg, J. X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11 beta-substituted steroids. J. Biol. Chem., 287:20333-20343, 2012 Cited by PubMed: 22535964 DOI: 10.1074/jbc.M111.308403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation