4APU
PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids
Summary for 4APU
Entry DOI | 10.2210/pdb4apu/pdb |
Related | 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2W8Y 3ZR7 3ZRA 3ZRB 4A2J |
Descriptor | PROGESTERONE RECEPTOR, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | transcription, asoprisnil, partial agonist |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401 |
Total number of polymer chains | 2 |
Total formula weight | 60930.81 |
Authors | Lusher, S.J.,Raaijmakers, H.C.A.,Bosch, R.,Vu-Pham, D.,McGuire, R.,Oubrie, A.,de Vlieg, J. (deposition date: 2012-04-06, release date: 2012-04-25, Last modification date: 2023-12-20) |
Primary citation | Lusher, S.J.,Raaijmakers, H.C.,Vu-Pham, D.,Kazemier, B.,Bosch, R.,McGuire, R.,Azevedo, R.,Hamersma, H.,Dechering, K.,Oubrie, A.,van Duin, M.,de Vlieg, J. X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11 beta-substituted steroids. J. Biol. Chem., 287:20333-20343, 2012 Cited by PubMed: 22535964DOI: 10.1074/jbc.M111.308403 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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