1ZUC
Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget
Summary for 1ZUC
Entry DOI | 10.2210/pdb1zuc/pdb |
Descriptor | Progesterone receptor, 5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | progesterone receptor, nonsteroidal agonist, tanaproget, progesterone, hormone, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus. Isoform A: Nucleus: P06401 |
Total number of polymer chains | 2 |
Total formula weight | 60282.56 |
Authors | Zhang, Z.,Olland, A.M.,Zhu, Y.,Cohen, J.,Berrodin, T.,Chippari, S.,Appavu, C.,Li, S.,Wilhem, J.,Chopra, R.,Fensome, A.,Zhang, P.,Wrobel, J.,Unwalla, R.J.,Lyttle, C.R.,Winneker, R.C. (deposition date: 2005-05-30, release date: 2005-07-05, Last modification date: 2023-08-23) |
Primary citation | Zhang, Z.,Olland, A.M.,Zhu, Y.,Cohen, J.,Berrodin, T.,Chippari, S.,Appavu, C.,Li, S.,Wilhem, J.,Chopra, R.,Fensome, A.,Zhang, P.,Wrobel, J.,Unwalla, R.J.,Lyttle, C.R.,Winneker, R.C. Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget J.Biol.Chem., 280:28468-28475, 2005 Cited by PubMed: 15937332DOI: 10.1074/jbc.M504144200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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