1ZUC

Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget

Summary for 1ZUC

• Entry DOI: 10.2210/pdb1zuc/pdb
• Descriptor: Progesterone receptor, 5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: progesterone receptor, nonsteroidal agonist, tanaproget, progesterone, hormone, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus. Isoform A: Nucleus: P06401
• Total number of polymer chains: 2
• Total formula weight: 60282.56

Authors

Zhang, Z.,Olland, A.M.,Zhu, Y.,Cohen, J.,Berrodin, T.,Chippari, S.,Appavu, C.,Li, S.,Wilhem, J.,Chopra, R.,Fensome, A.,Zhang, P.,Wrobel, J.,Unwalla, R.J.,Lyttle, C.R.,Winneker, R.C. (deposition date: 2005-05-30, release date: 2005-07-05, Last modification date: 2023-08-23)

• Primary citation: Zhang, Z.,Olland, A.M.,Zhu, Y.,Cohen, J.,Berrodin, T.,Chippari, S.,Appavu, C.,Li, S.,Wilhem, J.,Chopra, R.,Fensome, A.,Zhang, P.,Wrobel, J.,Unwalla, R.J.,Lyttle, C.R.,Winneker, R.C.; Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget; J.Biol.Chem., 280:28468-28475, 2005; PubMed: 15937332; DOI: 10.1074/jbc.M504144200

Experimental method

X-RAY DIFFRACTION (2 Å)