2W8Y
RU486 bound to the progesterone receptor in a destabilized agonistic conformation
Summary for 2W8Y
Entry DOI | 10.2210/pdb2w8y/pdb |
Related | 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A |
Descriptor | PROGESTERONE RECEPTOR, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, SULFATE ION, ... (6 entities in total) |
Functional Keywords | receptor, progesterone receptor, ru-486, mifepristone |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401 |
Total number of polymer chains | 2 |
Total formula weight | 60822.34 |
Authors | Raaijmakers, H.C.A.,Versteeg, J.,Uitdehaag, J.C.M. (deposition date: 2009-01-20, release date: 2009-04-28, Last modification date: 2024-05-08) |
Primary citation | Raaijmakers, H.C.A.,Versteegh, J.,Uitdehaag, J.C.M. The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation. J.Biol.Chem., 284:19572-, 2009 Cited by PubMed: 19372222DOI: 10.1074/JBC.M109.007872 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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