2W8Y
RU486 bound to the progesterone receptor in a destabilized agonistic conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROGESTERONE RECEPTOR | polymer | 260 | 29968.1 | 2 | UniProt (P06401) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | PR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 3 |
| 2 | C (A) | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | non-polymer | 429.6 | 1 | Chemie (486) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E (B) | (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one | non-polymer | 298.4 | 1 | Chemie (NDR) | |||
| 5 | F (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | G, H (A, B) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59936.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 886.1 | |
| All* | Total formula weight | 60822.3 |
