2W8Y

RU486 bound to the progesterone receptor in a destabilized agonistic conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PROGESTERONE RECEPTOR	polymer	260	29968.1	2	UniProt (P06401) Pfam (PF00104)	HOMO SAPIENS (HUMAN)	PR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 3
2	C (A)	11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE	non-polymer		429.6	1	Chemie (486) PubChem (16394559) PubChem (20651195) PubChem (25260940) PubChem (40785059) PubChem (55245) PubChem (16758830) PubChem (18649237) PubChem (1756360) PubChem (49800048) PubChem (26339468) PubChem (374394) PubChem (73897308) PubChem (70407138) PubChem (4196) PubChem (6604445) PubChem (124300838) PubChem (124404360) PubChem (9910521) PubChem (6426861) PubChem (6569219) PubChem (6604870) PubChem (6712024) PubChem (7048587) PubChem (7048709) PubChem (7048710) PubChem (11743390) PubChem (10387949) PubChem (124338910) PubChem (13080184) PubChem (13080185) PubChem (13080187) PubChem (130205874) PubChem (131632911) PubChem (133269675) PubChem (133688789) PubChem (138113540) PubChem (139025155) PubChem (145874921) PubChem (170056603) PubChem (170130266)
3	D (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	E (B)	(14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one	non-polymer		298.4	1	Chemie (NDR) PubChem (16757709) PubChem (18530263) PubChem (4536) PubChem (29985964) PubChem (40459118) PubChem (40469487) PubChem (40469488) PubChem (40520537) PubChem (42051932) PubChem (44660320) PubChem (66398) PubChem (21233743) PubChem (60070964) PubChem (1201537) PubChem (1427620) PubChem (1505526) PubChem (3080887) PubChem (6230) PubChem (71751191) PubChem (6552016) PubChem (5702093) PubChem (125037540) PubChem (6432649) PubChem (6604204) PubChem (7048591) PubChem (7048726) PubChem (11865444) PubChem (9839243) PubChem (124226209) PubChem (124226210) PubChem (11865443) PubChem (11865445) PubChem (11865446) PubChem (12313533) PubChem (124897015) PubChem (125037541) PubChem (129009914) PubChem (132051361) PubChem (143334617) PubChem (145714469) PubChem (164781727) PubChem (165044433)
5	F (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	G, H (A, B)	water	water		18.0	200	Chemie (HOH)

Sequence modifications

A, B: 674 - 677 (PDB: 2W8Y)
A, B: 678 - 933 (UniProt: P06401)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59936.2
Non-Polymers*	Number of molecules	4
	Total formula weight	886.1
All*	Total formula weight	60822.3

*Water molecules are not included.