2W8Y

RU486 bound to the progesterone receptor in a destabilized agonistic conformation

Summary for 2W8Y

Related2C7A 1A28 1ZUC 1SQN 1SR7 1E3K
DescriptorPROGESTERONE RECEPTOR, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, SULFATE ION, ... (6 entities in total)
Functional Keywordsreceptor, progesterone receptor, ru-486, mifepristone
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane  P06401
Total number of polymer chains2
Total molecular weight60822.34
Authors
Raaijmakers, H.C.A.,Versteeg, J.,Uitdehaag, J.C.M. (deposition date: 2009-01-20, release date: 2009-04-28, Last modification date: 2017-12-27)
Primary citation
Raaijmakers, H.C.A.,Versteegh, J.,Uitdehaag, J.C.M.
The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.
J.Biol.Chem., 284:19572-, 2009
PubMed: 19372222 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M109.007872
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.233201.1%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution