4APU
PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE OR8 A 1933 |
| Chain | Residue |
| A | LEU715 |
| A | PHE778 |
| A | MET801 |
| A | LEU887 |
| A | CYS891 |
| A | LEU718 |
| A | ASN719 |
| A | LEU721 |
| A | GLY722 |
| A | GLN725 |
| A | TRP755 |
| A | MET756 |
| A | MET759 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1934 |
| Chain | Residue |
| A | PRO737 |
| A | GLY738 |
| A | ARG740 |
| A | ASN741 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE A2K B 1933 |
| Chain | Residue |
| B | LEU718 |
| B | ASN719 |
| B | LEU721 |
| B | GLY722 |
| B | GLN725 |
| B | TRP755 |
| B | MET756 |
| B | MET759 |
| B | ARG766 |
| B | PHE778 |
| B | LEU797 |
| B | MET801 |
| B | TYR890 |
| B | CYS891 |
| B | THR894 |
| B | PHE905 |
| B | MET909 |
| B | ILE913 |
| B | HOH2018 |
| B | HOH2030 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 144 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | LYS731-GLN803 | |
| B | LYS731-GLN803 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | LYS731-ILE751 | |
| A | SER767-GLU791 | |
| B | LYS731-ILE751 | |
| B | SER767-GLU791 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9620806 |
| Chain | Residue | Details |
| A | PHE930 | |
| B | PHE930 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:11110801 |
| Chain | Residue | Details |
| A | GLN840 | |
| B | GLN840 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:17020914 |
| Chain | Residue | Details |
| A | GLU695 | |
| B | GLU695 |
