4A2J

PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids

Summary for 4A2J

• Entry DOI: 10.2210/pdb4a2j/pdb
• Related: 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2W8Y 3ZR7 3ZRA 3ZRB 4A2K 4APU
• Descriptor: PROGESTERONE RECEPTOR, 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transcription, partial agonist
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
• Total number of polymer chains: 2
• Total formula weight: 60931.42

Authors

Lusher, S.J.,Raaijmakers, H.C.A.,Bosch, R.,Vu-Pham, D.,McGuire, R.,Oubrie, A.,de Vlieg, J. (deposition date: 2011-09-27, release date: 2012-04-04, Last modification date: 2018-02-07)

• Primary citation: Lusher, S.J.,Raaijmakers, H.C.,Vu-Pham, D.,Kazemier, B.,Bosch, R.,McGuire, R.,Azevedo, R.,Hamersma, H.,Dechering, K.,Oubrie, A.,van Duin, M.,de Vlieg, J.; X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11 beta-substituted steroids.; J. Biol. Chem., 287:20333-20343, 2012; PubMed: 22535964; DOI: 10.1074/jbc.M111.308403

Experimental method

X-RAY DIFFRACTION (2 Å)