1SQN
Progesterone Receptor Ligand Binding Domain with bound Norethindrone
Summary for 1SQN
| Entry DOI | 10.2210/pdb1sqn/pdb |
| Related | 1A28 1E3K 1ZYX |
| Descriptor | progesterone receptor, (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one (3 entities in total) |
| Functional Keywords | progesterone receptor; nuclear receptor; steroid receptor; norethindrone; birth control, hormone-growth factor receptor complex, hormone/growth factor receptor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401 |
| Total number of polymer chains | 2 |
| Total formula weight | 60865.39 |
| Authors | Williams, S.P.,Madauss, K.P.,Deng, J.-S.,Austin, R.J.H.,Lambert, M.H.,McLay, I.,Pritchard, J.,Short, S.A.,Stewart, E.L.,Uings, I.J. (deposition date: 2004-03-19, release date: 2004-07-27, Last modification date: 2023-08-23) |
| Primary citation | Madauss, K.P.,Deng, J.-S.,Austin, R.J.H.,Lambert, M.H.,McLay, I.,Pritchard, J.,Short, S.A.,Stewart, E.L.,Uings, I.J.,Williams, S.P. Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes J.Med.Chem., 47:3381-3387, 2004 Cited by PubMed: 15189034DOI: 10.1021/jm030640n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.451 Å) |
Structure validation
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