3ZR7

Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators

Summary for 3ZR7

• Entry DOI: 10.2210/pdb3zr7/pdb
• Related: 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2W8Y 3ZRA 3ZRB
• Descriptor: PROGESTERONE RECEPTOR, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: receptor, agonist, antagonist
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
• Total number of polymer chains: 2
• Total formula weight: 61650.86

Authors

Lusher, S.J.,Raaijmakers, H.C.A.,Vu-Pham, D.,Dechering, K.,Wai Lam, T.,Brown, A.R.,Hamilton, N.M.,Nimz, O.,Azevedo, R.,McGuire, R.,Oubrie, A.,de Vlieg, J. (deposition date: 2011-06-15, release date: 2011-08-17, Last modification date: 2017-12-27)

• Primary citation: Lusher, S.J.,Raaijmakers, H.C.,Vu-Pham, D.,Dechering, K.,Lam, T.W.,Brown, A.R.,Hamilton, N.M.,Nimz, O.,Bosch, R.,McGuire, R.,Oubrie, A.,de Vlieg, J.; Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.; J. Biol. Chem., 286:35079-35086, 2011; PubMed: 21849509; DOI: 10.1074/jbc.M111.273029

Experimental method

X-RAY DIFFRACTION (1.65 Å)