3ZR7
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators
Summary for 3ZR7
Entry DOI | 10.2210/pdb3zr7/pdb |
Related | 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2W8Y 3ZRA 3ZRB |
Descriptor | PROGESTERONE RECEPTOR, 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | receptor, agonist, antagonist |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401 |
Total number of polymer chains | 2 |
Total formula weight | 61650.86 |
Authors | Lusher, S.J.,Raaijmakers, H.C.A.,Vu-Pham, D.,Dechering, K.,Wai Lam, T.,Brown, A.R.,Hamilton, N.M.,Nimz, O.,Azevedo, R.,McGuire, R.,Oubrie, A.,de Vlieg, J. (deposition date: 2011-06-15, release date: 2011-08-17, Last modification date: 2024-05-08) |
Primary citation | Lusher, S.J.,Raaijmakers, H.C.,Vu-Pham, D.,Dechering, K.,Lam, T.W.,Brown, A.R.,Hamilton, N.M.,Nimz, O.,Bosch, R.,McGuire, R.,Oubrie, A.,de Vlieg, J. Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators. J. Biol. Chem., 286:35079-35086, 2011 Cited by PubMed: 21849509DOI: 10.1074/jbc.M111.273029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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