4A2J
PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROGESTERONE RECEPTOR | polymer | 260 | 29968.1 | 2 | UniProt (P06401) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | PR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 3 |
| 2 | C, E (A, B) | 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME | non-polymer | 449.6 | 2 | Chemie (AS0) PubChem (22667303) PubChem (57375512) PubChem (89507634) PubChem (138642908) PubChem (72809410) PubChem (73952159) PubChem (88291172) PubChem (118333849) PubChem (156327) PubChem (6440511) PubChem (9577221) PubChem (133637885) PubChem (137699584) PubChem (146157898) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A, B: 678 - 933 (UniProt: P06401)
| PDB | External Database | Details |
|---|---|---|
| Gly 674 | - | expression tag |
| Ser 675 | - | expression tag |
| His 676 | - | expression tag |
| Met 677 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59936.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 995.2 | |
| All* | Total formula weight | 60931.4 |
