2OVH

Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT

Summary for 2OVH

• Entry DOI: 10.2210/pdb2ovh/pdb
• Related: 1A28 2OVM
• Descriptor: Progesterone receptor, SMRT peptide, 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, ... (4 entities in total)
• Functional Keywords: progesterone receptor, pr, nuclear receptor, steroid receptor, co-repressor, asoprisnil, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
• Total number of polymer chains: 2
• Total formula weight: 31916.56

Authors

Madauss, K.P.,Deng, S.-J.,Short, S.A.,Stewart, E.L.,Williams, S.P. (deposition date: 2007-02-13, release date: 2007-03-20, Last modification date: 2024-03-13)

• Primary citation: Madauss, K.P.,Grygielko, E.T.,Deng, S.J.,Sulpizio, A.C.,Stanley, T.B.,Wu, C.,Short, S.A.,Thompson, S.K.,Stewart, E.L.,Laping, N.J.,Williams, S.P.,Bray, J.D.; A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.; Mol.Endocrinol., 21:1066-1081, 2007; PubMed: 17356170; DOI: 10.1210/me.2006-0524

Experimental method

X-RAY DIFFRACTION (2 Å)