3G8O

Progesterone Receptor with bound Pyrrolidine 1

Replaces:  3G8N

Summary for 3G8O

• Entry DOI: 10.2210/pdb3g8o/pdb
• Related: 3HQ5
• Descriptor: Progesterone receptor, N~2~-[4-cyano-3-(trifluoromethyl)phenyl]-N,N-dimethyl-N~2~-(2,2,2-trifluoroethyl)-L-alaninamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: progesterone receptor, steroid hormone receptor, nuclear receptor, pr, progesterone, alpha helical sandwich, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, transcription regulation, zinc-finger
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
• Total number of polymer chains: 2
• Total formula weight: 61387.44

Authors

Thompson, S.K.,Washburn, D.G.,Madauss, K.P.,Williams, S.P.,Stewart, E.L. (deposition date: 2009-02-12, release date: 2010-02-16, Last modification date: 2023-09-06)

• Primary citation: Thompson, S.K.,Washburn, D.G.,Frazee, J.S.,Madauss, K.P.,Hoang, T.H.,Lapinski, L.,Grygielko, E.T.,Glace, L.E.,Trizna, W.,Williams, S.P.,Duraiswami, C.,Bray, J.D.,Laping, N.J.; Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.; Bioorg.Med.Chem.Lett., 19:4777-4780, 2009; PubMed: 19595590; DOI: 10.1016/j.bmcl.2009.06.055

Experimental method

X-RAY DIFFRACTION (1.9 Å)