3HQ5

Progesterone Receptor bound to an Alkylpyrrolidine ligand.

Summary for 3HQ5

• Entry DOI: 10.2210/pdb3hq5/pdb
• Descriptor: Progesterone receptor, SULFATE ION, 2-chloro-4-{[(3S)-1-methylpyrrolidin-3-yl][2-(trifluoromethyl)benzyl]amino}benzonitrile, ... (5 entities in total)
• Functional Keywords: nuclear receptor, progesterone receptor, pr, alternative splicing, cytoplasm, dna-binding, isopeptide bond, lipid-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, steroid-binding, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, hormone binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 60465.37

Authors

Madauss, K.P.,Williams, S.P.,Washburn, D.G. (deposition date: 2009-06-05, release date: 2010-03-02, Last modification date: 2024-02-21)

• Primary citation: Thompson, S.K.,Washburn, D.G.,Frazee, J.S.,Madauss, K.P.,Hoang, T.H.,Lapinski, L.,Grygielko, E.T.,Glace, L.E.,Trizna, W.,Williams, S.P.,Duraiswami, C.,Bray, J.D.,Laping, N.J.; Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.; Bioorg.Med.Chem.Lett., 19:4777-4780, 2009; PubMed: 19595590; DOI: 10.1016/j.bmcl.2009.06.055

Experimental method

X-RAY DIFFRACTION (2.1 Å)