1JV2
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![BU of 1jv2 by Molmil](/molmil-images/mine/1jv2) | CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3 | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xiong, J.P, Stehle, T, Diefenbach, B, Zhang, R, Dunker, R, Scott, D, Joachimiak, A, Goodman, S.L, Arnaout, M.A. | 登録日 | 2001-08-28 | 公開日 | 2001-10-17 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science, 294, 2001
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4MMX
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![BU of 4mmx by Molmil](/molmil-images/mine/4mmx) | Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | 著者 | van Agthoven, J, Xiong, J, Arnaout, M.A. | 登録日 | 2013-09-09 | 公開日 | 2014-03-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
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4MMY
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![BU of 4mmy by Molmil](/molmil-images/mine/4mmy) | Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | 著者 | van Agthoven, J, Xiong, J, Arnaout, M.A. | 登録日 | 2013-09-09 | 公開日 | 2014-03-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.183 Å) | 主引用文献 | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
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1L5G
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![BU of 1l5g by Molmil](/molmil-images/mine/1l5g) | CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xiong, J.-P, Stehle, T, Zhang, R, Joachimiak, A, Frech, M, Goodman, S.L, Arnaout, M.A. | 登録日 | 2002-03-06 | 公開日 | 2002-04-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science, 296, 2002
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4MMZ
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![BU of 4mmz by Molmil](/molmil-images/mine/4mmz) | Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | 著者 | van Agthoven, J, Xiong, J, Arnaout, M.A. | 登録日 | 2013-09-09 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
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1M1X
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![BU of 1m1x by Molmil](/molmil-images/mine/1m1x) | CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+ | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xiong, J.-P, Stehle, T, Zhang, R, Joachimiak, A, Frech, M, Goodman, S.L, Arnaout, M.A. | 登録日 | 2002-06-20 | 公開日 | 2002-08-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science, 296, 2002
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6UJA
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![BU of 6uja by Molmil](/molmil-images/mine/6uja) | Integrin alpha-v beta-8 in complex with pro-TGF-beta1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | 登録日 | 2019-10-02 | 公開日 | 2020-02-05 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
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3HO5
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![BU of 3ho5 by Molmil](/molmil-images/mine/3ho5) | |
6UJC
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![BU of 6ujc by Molmil](/molmil-images/mine/6ujc) | Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6-RGD3 heavy chain Fab, ... | 著者 | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | 登録日 | 2019-10-02 | 公開日 | 2020-02-05 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
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6AVQ
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![BU of 6avq by Molmil](/molmil-images/mine/6avq) | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance | 分子名称: | Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ... | 著者 | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | 登録日 | 2017-09-04 | 公開日 | 2017-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (35 Å) | 主引用文献 | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance. Structure, 25, 2017
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6AVR
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![BU of 6avr by Molmil](/molmil-images/mine/6avr) | Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609 | 分子名称: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | 著者 | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | 登録日 | 2017-09-04 | 公開日 | 2017-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (35 Å) | 主引用文献 | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance. Structure, 25, 2017
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6V4P
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![BU of 6v4p by Molmil](/molmil-images/mine/6v4p) | Structure of the integrin AlphaIIbBeta3-Abciximab complex | 分子名称: | Abciximab, heavy chain, light chain, ... | 著者 | Nesic, D, Zhang, Y, Spasic, A, Li, J, Provasi, D, Filizola, M, Walz, T, Coller, B.S. | 登録日 | 2019-11-28 | 公開日 | 2020-02-05 | 最終更新日 | 2020-03-11 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex. Arterioscler Thromb Vasc Biol., 40, 2020
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2WG4
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![BU of 2wg4 by Molmil](/molmil-images/mine/2wg4) | Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium | 分子名称: | HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, SONIC HEDGEHOG PROTEIN N-PRODUCT, ... | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-15 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
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3IJE
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![BU of 3ije by Molmil](/molmil-images/mine/3ije) | Crystal structure of the complete integrin alhaVbeta3 ectodomain plus an Alpha/beta transmembrane fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Xiong, J.-P, Mahalingham, B, Rui, X, Hyman, B.T, Goodman, S.L, Arnaout, M.A. | 登録日 | 2009-08-04 | 公開日 | 2009-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J.Cell Biol., 186, 2009
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6MK0
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![BU of 6mk0 by Molmil](/molmil-images/mine/6mk0) | Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161 | 分子名称: | (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | van Agthoven, J, Arnaout, M.A. | 登録日 | 2018-09-24 | 公開日 | 2019-09-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | 主引用文献 | Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations Acs Pharmacol Transl Sci, 2, 2019
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2WFX
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![BU of 2wfx by Molmil](/molmil-images/mine/2wfx) | Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog in the presence of calcium | 分子名称: | CALCIUM ION, HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, ... | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-15 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
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6AVU
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![BU of 6avu by Molmil](/molmil-images/mine/6avu) | Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609 | 分子名称: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | 著者 | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | 登録日 | 2017-09-04 | 公開日 | 2017-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (35 Å) | 主引用文献 | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance. Structure, 25, 2017
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6MSL
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![BU of 6msl by Molmil](/molmil-images/mine/6msl) | Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cystine Knot Protein 2.5D, ... | 著者 | van Agthoven, J.F, Arnaout, M.A. | 登録日 | 2018-10-16 | 公開日 | 2019-10-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.104 Å) | 主引用文献 | Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1. Structure, 27, 2019
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6MSU
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![BU of 6msu by Molmil](/molmil-images/mine/6msu) | Integrin alphaVBeta3 in complex with EETI-II 2.5F | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | van Agthoven, J.F, Arnaout, M.A. | 登録日 | 2018-10-18 | 公開日 | 2019-10-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1. Structure, 27, 2019
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6UJB
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![BU of 6ujb by Molmil](/molmil-images/mine/6ujb) | Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6D4 heavy chain Fab, ... | 著者 | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | 登録日 | 2019-10-02 | 公開日 | 2020-02-05 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
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6BXJ
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![BU of 6bxj by Molmil](/molmil-images/mine/6bxj) | Structure of a single-chain beta3 integrin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera protein of Integrin beta-3 and Integrin alpha-L, MAGNESIUM ION | 著者 | Thinn, A.M.M, Wang, Z, Zhou, D, Zhao, Y, Curtis, B.R, Zhu, J. | 登録日 | 2017-12-18 | 公開日 | 2018-10-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | Autonomous conformational regulation of beta3integrin and the conformation-dependent property of HPA-1a alloantibodies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6NAJ
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![BU of 6naj by Molmil](/molmil-images/mine/6naj) | |
2WG3
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![BU of 2wg3 by Molmil](/molmil-images/mine/2wg3) | Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DESERT HEDGEHOG PROTEIN N-PRODUCT, ... | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-15 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
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8GCD
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![BU of 8gcd by Molmil](/molmil-images/mine/8gcd) | Full length Integrin AlphaIIbBeta3 in inactive state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Huo, T, Wu, H, Wang, Z. | 登録日 | 2023-03-01 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture. Structure, 2024
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8GCE
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![BU of 8gce by Molmil](/molmil-images/mine/8gce) | The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Huo, T, Wu, H, Wang, Z. | 登録日 | 2023-03-01 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture. Structure, 2024
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