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PDB: 53 件
7PGN
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HHP-C in complex with glycosaminoglycan mimic SOS
分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
著者Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C.
登録日2021-08-14
公開日2021-12-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
7PGM
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HHIP-C in complex with heparin
分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein
著者Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C.
登録日2021-08-14
公開日2021-12-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
3HO4
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Crystal structure of Hedgehog-interacting protein (HHIP)
分子名称: Hedgehog-interacting protein
著者Hymowitz, S.G, Bosanac, I.
登録日2009-06-01
公開日2009-06-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
3HO3
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Crystal structure of Hedgehog-interacting protein (HHIP)
分子名称: Hedgehog-interacting protein
著者Bosanac, I, Hymowitz, S.G.
登録日2009-06-01
公開日2009-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
2WFT
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BU of 2wft by Molmil
Crystal structure of the human HIP ectodomain
分子名称: CHLORIDE ION, HEDGEHOG-INTERACTING PROTEIN, SODIUM ION
著者Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C.
登録日2009-04-15
公開日2009-06-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
4O02
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AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.
分子名称: 17E6 heavy chain, 17E6 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mahalingam, B, van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-12-13
公開日2014-04-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.605 Å)
主引用文献Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex.
J.Biol.Chem., 289, 2014
8ZJF
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Cryo-EM structure of human integrin alpha-E beta-7
分子名称: CALCIUM ION, Integrin alpha-E, Integrin beta-7, ...
著者Akasaka, H, Nureki, O, Kise, Y.
登録日2024-05-14
公開日2024-06-05
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Cryo-EM structure of I domain-containing integrin alpha E beta 7.
Biochem.Biophys.Res.Commun., 721, 2024
6DJP
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Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 68 heavy chain Fab, ...
著者Cormier, A, Campbell, M.G, Nishimura, S.L, Cheng, Y.
登録日2018-05-25
公開日2018-07-25
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Cryo-EM structure of the alpha v beta 8 integrin reveals a mechanism for stabilizing integrin extension.
Nat. Struct. Mol. Biol., 25, 2018
7LA4
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Integrin AlphaIIbBeta3-PT25-2 Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J.
登録日2021-01-05
公開日2022-01-12
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding.
Blood Adv, 5, 2021
4UM8
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Crystal structure of alpha V beta 6
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ...
著者Dong, X, Springer, T.A.
登録日2014-05-15
公開日2014-11-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.852 Å)
主引用文献Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
4CAK
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Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-IIb, ...
著者Choi, W.S, Rice, W.J, Stokes, D.L, Coller, B.S.
登録日2013-10-08
公開日2013-10-30
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (20.5 Å)
主引用文献Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding.
Blood, 122, 2013
8Y6B
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BU of 8y6b by Molmil
Structure of human LGI1-ADAM22 complex in space group P212121
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 22, ...
著者Liu, H, Xu, F.
登録日2024-02-02
公開日2024-02-14
実験手法X-RAY DIFFRACTION (3.49 Å)
主引用文献Structure of human LGI1-ADAM22 complex in space group P212121
To Be Published
1U8C
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A novel adaptation of the integrin PSI domain revealed from its crystal structure
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Xiong, J.P, Stehle, T, Goodman, S.L, Arnaout, M.A.
登録日2004-08-05
公開日2004-12-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A novel adaptation of the integrin PSI domain revealed from its crystal structure.
J.Biol.Chem., 279, 2004
4G1E
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Crystal structure of integrin alpha V beta 3 with coil-coiled tag.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Dong, X, Mi, L, Zhu, J, Wang, W, Luo, B, Springer, T.A.
登録日2012-07-10
公開日2012-12-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献AlphaV Beta3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
4G1M
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Re-refinement of alpha V beta 3 structure
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Springer, T.A, Mi, L, Zhu, J.
登録日2012-07-10
公開日2012-12-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
4Z81
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Crystal structure of AMA4 DI-DII-EGF1 from Toxoplasma gondii
分子名称: EGF family domain-containing protein, GLYCEROL
著者Parker, M.L, Boulanger, M.J.
登録日2015-04-08
公開日2015-12-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair.
Proc.Natl.Acad.Sci.USA, 113, 2016
8T2U
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BU of 8t2u by Molmil
Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
登録日2023-06-06
公開日2023-07-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
8T2V
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Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
登録日2023-06-06
公開日2023-07-26
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
5Y31
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Crystal structure of human LGI1-ADAM22 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 22, ...
著者Yamagata, A, Fukai, S.
登録日2017-07-27
公開日2018-05-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (7.125 Å)
主引用文献Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Nat Commun, 9, 2018
3FCS
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Structure of complete ectodomain of integrin aIIBb3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Zhu, J, Luo, B.-H, Xiao, T, Zhang, C, Nishida, N, Springer, T.A.
登録日2008-11-22
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
5Y2Z
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Crystal structure of human LGI1 EPTP-ADAM22 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yamagata, A, Fukai, S.
登録日2017-07-27
公開日2018-05-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Nat Commun, 9, 2018
4Z80
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Crystal structure of Toxoplasma gondii AMA4 DI-DII-EGF1 in complex with a 33 aa TgRON2L1 peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytoadherence-linked asexual protein, EGF family domain-containing protein, ...
著者Parker, M.L, Boulanger, M.J.
登録日2015-04-08
公開日2015-12-30
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair.
Proc.Natl.Acad.Sci.USA, 113, 2016
7NWL
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Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ...
著者Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
登録日2021-03-17
公開日2021-06-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
7NXD
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Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
登録日2021-03-18
公開日2021-08-25
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
3G5C
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Structural and biochemical studies on the ectodomain of human ADAM22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADAM 22, CALCIUM ION
著者Liu, H, Shim, A, Chen, X, He, X.
登録日2009-02-04
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Structural and biochemical studies on the ectodomain of human ADAM22
J.Biol.Chem., 2009

 

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