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PDB: 55 件
7RTG
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Crystal Structure of the Human Adenosine Deaminase 1
分子名称: Adenosine deaminase, ZINC ION
著者Ma, M.T, Lieberman, R.L, Blazeck, J, Jennings, M.R.
登録日2021-08-13
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.591 Å)
主引用文献Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation.
Acta Crystallogr D Struct Biol, 78, 2022
2Z7G
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Crystal structure of adenosine deaminase ligated with EHNA
分子名称: (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol, Adenosine deaminase, ZINC ION
著者Kinoshita, T.
登録日2007-08-20
公開日2008-07-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Conformational change of adenosine deaminase during ligand-exchange in a crystal
Biochem.Biophys.Res.Commun., 373, 2008
8QCH
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Human Adenosine deaminase-like protein in complex with compound AT8001
分子名称: Adenosine deaminase-like protein, DI(HYDROXYETHYL)ETHER, SODIUM ION, ...
著者Zimberger, C, canard, B, Ferron, F.
登録日2023-08-26
公開日2024-07-31
実験手法X-RAY DIFFRACTION (2.442 Å)
主引用文献The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution
Plos Biol., 2024
4GXW
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Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn
分子名称: Adenosine deaminase, CHLORIDE ION, ZINC ION
著者Vetting, M.W, Goble, A.M, Morisco, L.L, Wasserman, S.R, Sojitra, S, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
登録日2012-09-04
公開日2012-09-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn
To be Published
1KRM
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Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside
分子名称: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ZINC ION, adenosine deaminase
著者Kinoshita, T.
登録日2002-01-10
公開日2003-01-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside.
Acta Crystallogr.,Sect.D, 59, 2003
3EWC
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BU of 3ewc by Molmil
Crystal Structure of adenosine deaminase from Plasmodial vivax in complex with MT-coformycin
分子名称: (8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Adenosine deaminase, ZINC ION
著者Schramm, V.L, Almo, S.C, Cassera, M.B, Ho, M.C.
登録日2008-10-14
公開日2009-09-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
Biochemistry, 48, 2009
3EWD
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Crystal structure of adenosine deaminase mutant (delta Asp172) from Plasmodium vivax in complex with MT-coformycin
分子名称: (8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Adenosine deaminase, ZINC ION
著者Schramm, V.L, Almo, S.C, Cassera, M.B, Ho, M.C.
登録日2008-10-14
公開日2009-09-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
Biochemistry, 48, 2009
3RYS
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The crystal structure of adenine deaminase (AAur1117) from Arthrobacter aurescens
分子名称: ADENINE, Adenosine deaminase 1, ZINC ION
著者Zhang, Z, Goble, A.M, Raushel, F.M, Swaminathan, S.
登録日2011-05-11
公開日2011-05-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献The crystal structure of adenine deaminase (AAur1117) from Arthrobacter aurescens
To be Published
1FKW
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MURINE ADENOSINE DEAMINASE (D295E)
分子名称: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1996-02-29
公開日1996-08-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
1FKX
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MURINE ADENOSINE DEAMINASE (D296A)
分子名称: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1996-02-29
公開日1996-08-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
3T1G
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Engineering of organophosphate hydrolase by computational design and directed evolution
分子名称: CALCIUM ION, ZINC ION, organophosphate hydrolase
著者Takeuchi, R, Stoddard, B.L.
登録日2011-07-21
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nat.Chem.Biol., 8, 2012
2E1W
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Crystal structure of adenosine deaminase complexed with potent inhibitors
分子名称: 1-{(1R,2S)-2-HYDROXY-1-[2-(1-NAPHTHYL)ETHYL]PROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
著者Kinoshita, T.
登録日2006-10-30
公開日2006-11-07
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors
J.Med.Chem., 47, 2004
6N91
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Crystal Structure of Adenosine Deaminase from Vibrio cholerae Complexed with Pentostatin (Deoxycoformycin)
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYCOFORMYCIN, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ...
著者Maltseva, N, Kim, Y, Endres, M, Welk, L, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2018-11-30
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal Structure of Adenosine Deaminase from Vibrio cholerae Complexed with Pentostatin (Deoxycoformycin) (CASP target)
To Be Published
6N9M
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Crystal Structure of Adenosine Deaminase from Salmonella typhimurium with Pentostatin (Deoxycoformycin)
分子名称: 2'-DEOXYCOFORMYCIN, Adenosine deaminase, CALCIUM ION, ...
著者Maltseva, N, Kim, Y, Grimshaw, S, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2018-12-03
公開日2019-02-06
実験手法X-RAY DIFFRACTION (1.449 Å)
主引用文献Crystal Structure of Adenosine Deaminase from Salmonella typhimurium Complexed with Pentostatin (Deoxycoformycin) (CASP target)
To Be Published
1A4L
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BU of 1a4l by Molmil
ADA STRUCTURE COMPLEXED WITH DEOXYCOFORMYCIN AT PH 7.0
分子名称: 2'-DEOXYCOFORMYCIN, ADENOSINE DEAMINASE, ZINC ION
著者Wang, Z, Quiocho, F.A.
登録日1998-01-31
公開日1998-10-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
1A4M
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ADA STRUCTURE COMPLEXED WITH PURINE RIBOSIDE AT PH 7.0
分子名称: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
著者Wang, Z, Quiocho, F.A.
登録日1998-01-31
公開日1998-10-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
2PGF
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BU of 2pgf by Molmil
Crystal structure of adenosine deaminase from Plasmodium vivax in complex with adenosine
分子名称: ACETONITRILE, ADENOSINE, ZINC ION, ...
著者Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2007-04-09
公開日2007-04-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
2PGR
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BU of 2pgr by Molmil
Crystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin
分子名称: 2'-DEOXYCOFORMYCIN, ACETONITRILE, ZINC ION, ...
著者Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2007-04-10
公開日2007-04-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
1ADD
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A PRE-TRANSITION STATE MIMIC OF AN ENZYME: X-RAY STRUCTURE OF ADENOSINE DEAMINASE WITH BOUND 1-DEAZA-ADENOSINE AND ZINC-ACTIVATED WATER
分子名称: 1-DEAZA-ADENOSINE, ADENOSINE DEAMINASE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1992-12-22
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water.
Biochemistry, 32, 1993
2QVN
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Crystal structure of adenosine deaminase from Plasmodium vivax in complex with guanosine
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Adenosine deaminase, GUANOSINE
著者Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2007-08-08
公開日2007-09-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
J.Mol.Biol., 381, 2008
3IAR
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The crystal structure of human adenosine deaminase
分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Adenosine deaminase, GLYCEROL, ...
著者Ugochukwu, E, Zhang, Y, Hapka, E, Yue, W.W, Bray, J.E, Muniz, J, Burgess-Brown, N, Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2009-07-14
公開日2009-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献The crystal structure of human adenosine deaminase
To be Published
1WXY
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Crystal structure of adenosine deaminase ligated with a potent inhibitor
分子名称: Adenosine deaminase, N-[4,5-BIS(4-HYDROXYPHENYL)-1,3-THIAZOL-2-YL]HEXANAMIDE, ZINC ION
著者Kinoshita, T.
登録日2005-02-02
公開日2005-08-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis of Compound Recognition by Adenosine Deaminase
Biochemistry, 44, 2005
1WXZ
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Crystal structure of adenosine deaminase ligated with a potent inhibitor
分子名称: 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION
著者Kinoshita, T.
登録日2005-02-02
公開日2005-08-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism
J.Med.Chem., 48, 2005
3KM8
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Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine
分子名称: 9-DEAZAINOSINE, Adenosine deaminase, ZINC ION
著者Fan, X, Gao, Y.
登録日2009-11-10
公開日2010-10-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Catalytic Mechanism of Adenosine Deaminase from Mouse: An Experimental and Theoretical Study
To be Published
2ADA
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ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS
分子名称: 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
著者Wilson, D.K, Quiocho, F.A.
登録日1994-12-02
公開日1995-03-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.
Science, 252, 1991

 

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