1WXZ
Crystal structure of adenosine deaminase ligated with a potent inhibitor
Summary for 1WXZ
Entry DOI | 10.2210/pdb1wxz/pdb |
Descriptor | Adenosine deaminase, ZINC ION, 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | beta barel, hydrolase |
Biological source | Bos taurus (cattle) |
Cellular location | Cell membrane ; Peripheral membrane protein ; Extracellular side : P56658 |
Total number of polymer chains | 1 |
Total formula weight | 40831.96 |
Authors | Kinoshita, T. (deposition date: 2005-02-02, release date: 2005-08-16, Last modification date: 2024-03-13) |
Primary citation | Terasaka, T.,Tsuji, K.,Kato, T.,Nakanishi, I.,Kinoshita, T.,Kato, Y.,Kuno, M.,Inoue, T.,Tanaka, K.,Nakamura, K. Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism J.Med.Chem., 48:4750-4753, 2005 Cited by PubMed: 16033254DOI: 10.1021/jm050413g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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