Crystal structure of adenosine deaminase ligated with a potent inhibitor

Summary for 1WXZ

DescriptorAdenosine deaminase, ZINC ION, 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsbeta barel, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationCell membrane ; Peripheral membrane protein ; Extracellular side  P56658
Total number of polymer chains1
Total molecular weight40831.96
Kinoshita, T. (deposition date: 2005-02-02, release date: 2005-08-16, Last modification date: 2017-10-11)
Primary citation
Terasaka, T.,Tsuji, K.,Kato, T.,Nakanishi, I.,Kinoshita, T.,Kato, Y.,Kuno, M.,Inoue, T.,Tanaka, K.,Nakamura, K.
Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism
J.Med.Chem., 48:4750-4753, 2005
PubMed: 16033254 (PDB entries with the same primary citation)
DOI: 10.1021/jm050413g
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers252.9%11.8%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1wxz
no rotation
Molmil generated image of 1wxz
rotated about x axis by 90°
Molmil generated image of 1wxz
rotated about y axis by 90°
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