1WXZ
Crystal structure of adenosine deaminase ligated with a potent inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004000 | molecular_function | adenosine deaminase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006154 | biological_process | adenosine catabolic process |
| A | 0007155 | biological_process | cell adhesion |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009168 | biological_process | purine ribonucleoside monophosphate biosynthetic process |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019239 | molecular_function | deaminase activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0042110 | biological_process | T cell activation |
| A | 0043103 | biological_process | hypoxanthine salvage |
| A | 0046103 | biological_process | inosine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046936 | molecular_function | 2'-deoxyadenosine deaminase activity |
| A | 0060169 | biological_process | negative regulation of adenosine receptor signaling pathway |
| A | 0060205 | cellular_component | cytoplasmic vesicle lumen |
| A | 0070161 | cellular_component | anchoring junction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | HIS15 |
| A | HIS17 |
| A | HIS214 |
| A | ASP295 |
| A | HOH423 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FRL A 401 |
| Chain | Residue |
| A | LEU62 |
| A | PHE65 |
| A | LEU106 |
| A | TRP117 |
| A | GLY184 |
| A | ASP185 |
| A | VAL218 |
| A | ASP295 |
| A | ASP296 |
| A | HOH430 |
| A | HOH511 |
| A | HOH528 |
| A | HIS17 |
| A | ASP19 |
| A | LEU58 |
| A | PHE61 |
Functional Information from PROSITE/UniProt
| site_id | PS00485 |
| Number of Residues | 7 |
| Details | A_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP |
| Chain | Residue | Details |
| A | SER291-PRO297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P03958 |
| Chain | Residue | Details |
| A | VAL218 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12554940, ECO:0000269|PubMed:14709046, ECO:0000269|PubMed:15139750, ECO:0000269|PubMed:15213224, ECO:0000269|PubMed:15239652, ECO:0000269|PubMed:15695814, ECO:0000269|PubMed:16033254, ECO:0000269|PubMed:16060665, ECO:0000269|PubMed:18549808, ECO:0007744|PDB:1KRM, ECO:0007744|PDB:1NDV, ECO:0007744|PDB:1NDW, ECO:0007744|PDB:1NDY, ECO:0007744|PDB:1NDZ, ECO:0007744|PDB:1O5R, ECO:0007744|PDB:1QXL, ECO:0007744|PDB:1VFL |
| Chain | Residue | Details |
| A | VAL16 | |
| A | LEU18 | |
| A | ALA215 | |
| A | ASP296 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12554940, ECO:0000269|PubMed:14709046, ECO:0000269|PubMed:15139750, ECO:0000269|PubMed:15239652, ECO:0000269|PubMed:16033254, ECO:0000269|PubMed:16060665, ECO:0000269|PubMed:18549808, ECO:0007744|PDB:1NDW, ECO:0007744|PDB:1NDY, ECO:0007744|PDB:1NDZ, ECO:0007744|PDB:1O5R, ECO:0007744|PDB:1QXL |
| Chain | Residue | Details |
| A | GLY20 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14709046, ECO:0000269|PubMed:16060665, ECO:0007744|PDB:1NDY, ECO:0007744|PDB:1WXY |
| Chain | Residue | Details |
| A | ASP185 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12554940, ECO:0000269|PubMed:14709046, ECO:0000269|PubMed:15139750, ECO:0000269|PubMed:15239652, ECO:0000269|PubMed:16033254, ECO:0000269|PubMed:18549808, ECO:0007744|PDB:1NDW, ECO:0007744|PDB:1NDY, ECO:0007744|PDB:1NDZ, ECO:0007744|PDB:1O5R, ECO:0007744|PDB:1QXL |
| Chain | Residue | Details |
| A | PRO297 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Important for interaction with adenosine receptors and increasing their affinity for agonists => ECO:0000250|UniProtKB:P00813 |
| Chain | Residue | Details |
| A | PRO59 | |
| A | ALA63 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Important for catalytic activity => ECO:0000250|UniProtKB:P03958 |
| Chain | Residue | Details |
| A | GLY239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00813 |
| Chain | Residue | Details |
| A | GLN3 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00813 |
| Chain | Residue | Details |
| A | PRO55 | |
| A | THR233 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a4l |
| Chain | Residue | Details |
| A | HIS238 | |
| A | TYR240 | |
| A | GLU217 | |
| A | ASP295 |
