1NDZ
Crystal Structure of Adenosine Deaminase Complexed with FR235999
Summary for 1NDZ
| Entry DOI | 10.2210/pdb1ndz/pdb |
| Related | 1NDV 1NDW 1NDY |
| Descriptor | Adenosine Deaminase, ZINC ION, 1-((1R)-1-(HYDROXYMETHYL)-3-(6-((3-(1-METHYL-1H-BENZIMIDAZOL-2-YL)PROPANOYL)AMINO)-1H-INDOL-1-YL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, ... (4 entities in total) |
| Functional Keywords | sbdd, tim-barrel, hydrolase |
| Biological source | Bos taurus (cattle) |
| Cellular location | Cell membrane; Peripheral membrane protein; Extracellular side (By similarity): P56658 |
| Total number of polymer chains | 1 |
| Total formula weight | 40906.64 |
| Authors | Kinoshita, T. (deposition date: 2002-12-09, release date: 2003-12-09, Last modification date: 2024-03-13) |
| Primary citation | Terasaka, T.,Kinoshita, T.,Kuno, M.,Nakanishi, I. A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126:34-35, 2004 Cited by PubMed Abstract: We disclose herein the rapid discovery of the first highly potent (Ki = 7.7 nM) non-nucleoside adenosine deaminase (ADA) inhibitor based on the rational hybridization of two structurally distinct leads. Two micromolar inhibitors were discovered by a parallel rational design and random screening program, and individual crystal structures of bovine ADA in complexation with these inhibitors revealed several unknown binding sites and distinct binding modes. Using this information as the starting point, highly effective lead hybridization was achieved in only two structure-based drug design iterations. The conceptual approach illustrated by this example promises to be broadly useful in the search for new chemical entities and can contribute greatly to improve the overall efficiency and speed of drug discovery. PubMed: 14709046DOI: 10.1021/ja038606l PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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