Crystal structure of adenosine deaminase complexed with potent inhibitors

Replaces:  1V78

Summary for 2E1W

Related1V79 1V7A
DescriptorAdenosine deaminase, ZINC ION, 1-{(1R,2S)-2-HYDROXY-1-[2-(1-NAPHTHYL)ETHYL]PROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsbeta barrel, zinc, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationCell membrane; Peripheral membrane protein; Extracellular side (By similarity) P56658
Total number of polymer chains1
Total molecular weight40730.47
Kinoshita, T. (deposition date: 2006-10-30, release date: 2006-11-07, Last modification date: 2011-07-13)
Primary citation
Terasaka, T.,Okumura, H.,Tsuji, K.,Kato, T.,Nakanishi, I.,Kinoshita, T.,Kato, Y.,Kuno, M.,Seki, N.,Naoe, Y.,Inoue, T.,Tanaka, K.,Nakamura, K.
Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors
J.Med.Chem., 47:2728-2731, 2004
PubMed: 15139750 (PDB entries with the same primary citation)
DOI: 10.1021/jm0499559
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers182.0%19.7%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2e1w
no rotation
Molmil generated image of 2e1w
rotated about x axis by 90°
Molmil generated image of 2e1w
rotated about y axis by 90°
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