2PGR

Crystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin

Summary for 2PGR

Entry DOI	10.2210/pdb2pgr/pdb
Related	2PGF 2QVN
Descriptor	adenosine deaminase, ZINC ION, 2'-DEOXYCOFORMYCIN, ... (5 entities in total)
Functional Keywords	metallo-dependent hydrolase, structural genomics, medical structural genomics of pathogenic protozoa consortium, msgpp, structural genomics of pathogenic protozoa consortium, sgpp, psi, protein structure initiative, hydrolase
Biological source	Plasmodium vivax (malaria parasite P. vivax)
Total number of polymer chains	1
Total formula weight	43892.96
Authors	Larson, E.T.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (deposition date: 2007-04-10, release date: 2007-04-24, Last modification date: 2023-11-15)
Primary citation	Larson, E.T.,Deng, W.,Krumm, B.E.,Napuli, A.,Mueller, N.,Van Voorhis, W.C.,Buckner, F.S.,Fan, E.,Lauricella, A.,DeTitta, G.,Luft, J.,Zucker, F.,Hol, W.G.,Verlinde, C.L.,Merritt, E.A. Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381:975-988, 2008 Cited by PubMed: 18602399 DOI: 10.1016/j.jmb.2008.06.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation