2QVN

Crystal structure of adenosine deaminase from Plasmodium vivax in complex with guanosine

Summary for 2QVN

Entry DOI	10.2210/pdb2qvn/pdb
Related	2PGF 2PGR
Descriptor	Adenosine deaminase, GUANOSINE, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (4 entities in total)
Functional Keywords	metallo-dependent hydrolase, tim barrel, structural genomics, medical structural genomics of pathogenic protozoa consortium, msgpp, plasmodium, malaria, psi, protein structure initiative, hydrolase
Biological source	Plasmodium vivax SaI-1
Total number of polymer chains	1
Total formula weight	43967.71
Authors	Larson, E.T.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (deposition date: 2007-08-08, release date: 2007-09-04, Last modification date: 2023-11-15)
Primary citation	Larson, E.T.,Deng, W.,Krumm, B.E.,Napuli, A.,Mueller, N.,Van Voorhis, W.C.,Buckner, F.S.,Fan, E.,Lauricella, A.,DeTitta, G.,Luft, J.,Zucker, F.,Hol, W.G.,Verlinde, C.L.,Merritt, E.A. Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381:975-988, 2008 Cited by PubMed: 18602399 DOI: 10.1016/j.jmb.2008.06.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation