4NRU
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![BU of 4nru by Molmil](/molmil-images/mine/4nru) | Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative | 分子名称: | 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, MAGNESIUM ION, RNA dependent RNA polymerase | 著者 | Milani, M, Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Bolognesi, M. | 登録日 | 2013-11-27 | 公開日 | 2014-10-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. Plos One, 9, 2014
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4NLO
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![BU of 4nlo by Molmil](/molmil-images/mine/4nlo) | |
9CPO
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![BU of 9cpo by Molmil](/molmil-images/mine/9cpo) | |
8URB
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![BU of 8urb by Molmil](/molmil-images/mine/8urb) | |
7THM
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![BU of 7thm by Molmil](/molmil-images/mine/7thm) | SARS-CoV-2 nsp12/7/8 complex with a native N-terminus nsp9 | 分子名称: | MANGANESE (II) ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Osinski, A, Tagliabracci, V.S, Chen, Z, Li, Y. | 登録日 | 2022-01-11 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | The mechanism of RNA capping by SARS-CoV-2. Nature, 609, 2022
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7C2K
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![BU of 7c2k by Molmil](/molmil-images/mine/7c2k) | COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA (29-MER), ... | 著者 | Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z. | 登録日 | 2020-05-07 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Cell, 182, 2020
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7CTT
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![BU of 7ctt by Molmil](/molmil-images/mine/7ctt) | Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Peng, Q, Peng, R, Shi, Y. | 登録日 | 2020-08-20 | 公開日 | 2020-09-02 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir. Innovation (N Y), 2, 2021
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6XEZ
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![BU of 6xez by Molmil](/molmil-images/mine/6xez) | Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | 登録日 | 2020-06-14 | 公開日 | 2020-07-29 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell, 182, 2020
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8GY6
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8SQ9
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![BU of 8sq9 by Molmil](/molmil-images/mine/8sq9) | SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Small, G.I, Darst, S.A, Campbell, E.A. | 登録日 | 2023-05-04 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
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8SQK
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![BU of 8sqk by Molmil](/molmil-images/mine/8sqk) | SARS-CoV-2 replication-transcription complex bound to RNA-nsp9 and GDP-betaS, as a pre-catalytic deRNAylation/mRNA capping intermediate | 分子名称: | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Small, G.I, Darst, S.A, Campbell, E.A. | 登録日 | 2023-05-04 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
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8SQJ
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![BU of 8sqj by Molmil](/molmil-images/mine/8sqj) | SARS-CoV-2 replication-transcription complex bound to RNA-nsp9, as a noncatalytic RNA-nsp9 binding mode | 分子名称: | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Small, G.I, Darst, S.A, Campbell, E.A. | 登録日 | 2023-05-04 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
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6XQB
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![BU of 6xqb by Molmil](/molmil-images/mine/6xqb) | SARS-CoV-2 RdRp/RNA complex | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Liu, B, Shi, W, Yang, Y. | 登録日 | 2020-07-09 | 公開日 | 2020-07-29 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution To Be Published
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6YYT
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![BU of 6yyt by Molmil](/molmil-images/mine/6yyt) | Structure of replicating SARS-CoV-2 polymerase | 分子名称: | RNA product, ZINC ION, nsp12, ... | 著者 | Hillen, H.S, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P. | 登録日 | 2020-05-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure of replicating SARS-CoV-2 polymerase. Nature, 584, 2020
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7L1F
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![BU of 7l1f by Molmil](/molmil-images/mine/7l1f) | |
7KRN
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![BU of 7krn by Molmil](/molmil-images/mine/7krn) | Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2020-11-20 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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7KRP
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![BU of 7krp by Molmil](/molmil-images/mine/7krp) | Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHAPSO, MAGNESIUM ION, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2020-11-20 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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7KRO
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![BU of 7kro by Molmil](/molmil-images/mine/7kro) | Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2020-11-20 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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7UO4
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![BU of 7uo4 by Molmil](/molmil-images/mine/7uo4) | SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UOB
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![BU of 7uob by Molmil](/molmil-images/mine/7uob) | SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state | 分子名称: | 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UO9
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![BU of 7uo9 by Molmil](/molmil-images/mine/7uo9) | SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UO7
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![BU of 7uo7 by Molmil](/molmil-images/mine/7uo7) | SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UOE
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![BU of 7uoe by Molmil](/molmil-images/mine/7uoe) | SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state | 分子名称: | 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | 主引用文献 | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7OZV
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![BU of 7ozv by Molmil](/molmil-images/mine/7ozv) | SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G | 分子名称: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | 著者 | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | 登録日 | 2021-06-28 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat.Struct.Mol.Biol., 28, 2021
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7OZU
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![BU of 7ozu by Molmil](/molmil-images/mine/7ozu) | SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with A | 分子名称: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | 著者 | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | 登録日 | 2021-06-28 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat.Struct.Mol.Biol., 28, 2021
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